Brain Science Podcast #32: A Brief Introduction to Brain Anatomy

Episode 32 of the Brain Science Podcast is a whirlwind (55 minute) tour of brain anatomy.  It is based on David Bainbridge's new book: Beyond the Zonules of Zinn: A Fantastic Journey Through Your Brain (2008).  Click here for some of the key illustrations from the book.  I want to thank David for sharing these images, and I encourage everyone to read the book.

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Brain Science Podcast #31: Brain Rhythms with György Buzsáki

György Buzsáki, author of Rhythms of the Brain  (OUP 2006), is a professor of neuroscience at Rutgers University.  His book is a comprehensive review of the current state of research in the field of brain oscillations.  It includes the role of these oscillations in sleep and memory.  In Episode 31 of the Brain Science PodcastDr. Buzáki explains why the rhythms of the brain are important and reflects on why this field has been neglected by some neuroscientists.  I think he makes a convincing case for the position that these rhythms are an essential component of brain function.

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Scientists and References:

  • Stephen Strogatz: known for his discovery of "small world" architecture.: His 2003 bestseller Sync: The emerging science of spontaneous order is aimed at a general audience

  • Nancy Kopell: mathematician: Buzsaki recommends her review of the analytical approaches to neuronal oscillators: We got Rhythm: Dynamical Systems of the Nervous System. N Am Math Soc 47: 6-16 (2000).

  • Zoltán Néda (Bebes-Bolyai University Romania): the spontaneous synchronization of hand clapping

  • Hermann Haken: German laser physicist who studies bidirectional causation.

  • The Science of Structure: Synergetics (1984).

  • John O'Keefe (University College,  London): along with Lynn Nadel he discovered how the hippocampus forms a cognitive map of the world. He has shown how the timing of oscillations in the hippocampus are important.

  • "Independent rate and temporal coding in hippocampal pyramidal cells," by John Huxter, Neil Burgess, and John O'Keefe. Nature 425, 828-832 (23 October 2003).

  • David McCormick (Yale University): showed that neurons from the thalamus of a ferret can oscillate spontaneously.  He has also studied the oscillations of place cells in the hippocampus.

  • David Hubel and Thorston Wiesel: along with Vernon Montcastle, they pioneered the use of single neuron recordings in the neocortex of casts and monkeys.

  • Montcastle, VB (1997), "The Columnar Organization of the Neocortex." Brain 102:01-722.

  • Claude Shannon: founder of Information Theory.

  • Jan Born (University of Lübeck, Germany): experiments with how sleep improves both memory and problem solving.

Topics and questions:

  • Basics of oscillations and synchrony.

  • What functions are accomplished by brain rhythms?

  • The role of hippocampal ripples in memory.

  • What happens to our brain rhythms while we sleep.

  • The importance of synchrony in saving energy in the brain.

This episode will appeal to listeners with a background in math or engineering, but Dr. Buzsáki provides numerous everyday examples that make the material accessible to everyone.

The Evolution of Language (BSP 30)

Episode 30 of the Brain Science Podcast is a discussion of The First Word: The Search for the Origins of Language, by Christine Kenneally.  We focus mostly on the first part of the book, which tells the story of how the study of language evolution has grown from almost a banned subject to a new field of inquiry called evolutionary linguistics.  We also reflect on how recent findings in neuroscience like the importance of plasticity are influencing the field.

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Scientists discussed in the Episode:

*References:

*Additional references can be found in Kenneally's book and at the websites of the scientists listed above.  Also, be sure to check out Kenneally's blog for follow-up information.

Reading and the Brain with Dr. Maryanne Wolf (BSP 29)

Dr. Maryanne Wolf, Director of The Center for Reading and Language Research at Tufts University

Episode 29 of the Brain Science Podcast is an interview with cognitive neuroscientist, Dr. Maryanne Wolf, author of Proust and the Squid: The Story and Science of the Reading Brain.  I discussed her book in Episode 24, so this interview was an opportunity to ask her some follow-up questions, and to focus more on how children learn to read.  Dr. Wolf shares her ten years of experience helping children learn to read and developing programs to help children with problems like dyslexia.  She shares some practical advice for parents as well as her concerns about how reliance on the internet could influence reading skills.

I enjoyed the conversation and, while I especially want to share this episode with parents, I think Dr. Wolf gives everyone some interesting ideas to consider. 

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Links:

Maryanne Wolf

Edward Taub's Revolutionary Approach to Stroke Rehabilitation (BSP 28)

Edward Taub, PhD, pioneer of Constraint-Induced Movement Therapy

Episode 28 of the Brain Science Podcast is an interview with Dr. Edward Taub, who for the last 20+ years has been pioneering the use of Constraint-Induced Movement Therapy in the rehabilitation of stroke and other neurological disabilities.  I have talked about his work in previous episodes (including Episode 10 and Episode 26) as an important example of the practical implications of brain plasticity. 

In this interview,  Dr. Taub shares his personal experiences in the front lines of clinical research, including both its rewards and frustrations.  He also explains the basics of how constraint-induced therapy (CI Therapy) works and how his work is being expanded to help patients with a wide variety of problems including cerebral palsy, head trauma, multiple sclerosis, and focal hand dystonia.

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Links and References:

Dr. Taub recommends that interested listeners do their own Google search under "constraint-induced movement therapy" or CI Therapy, but I have included a few links below:

About Dr. Taub:

References:

  • Effect of Constraint-Induced Movement Therapy on Upper Extremity Function 3 to 9 Months After Stroke: The EXCITE Randomized Clinical Trial: Steven L. Wolf; Carolee J. Winstein; J. Philip Miller; EdwardTaub; Gitendra Uswatte; David Morris; Carol Giuliani; Kathye E. Light; Deborah Nichols-Larsen; JAMA, November 1, 2006;   296:   2095 - 2104.  (Free download)

  • Accompanying editorial: Stroke Recovery-Moving in an EXCITE-ing Direction: Andreas R. Luft, MD;  Daniel F. Hanley, MD; JAMA. 2006;296:2141-2143.  (Available for purchase)

Year-end Review for 2007 (BSP 27)

Episode 27 is a look back on the first 26 episodes of the Brain Science Podcast.

I look back on some of the main topics that we have explored including memory, consciousness, emotions, decision-making, body maps, and plasticity.  Then I talk a little about what I hope to do in the covering year.  This episode is a little more personal than most, and will mainly be of interest to regular listeners.  It includes some ideas about how you can help the Brain Science Podcast grow and prosper.

However, in preparing this episode, I went back over the past year's episodes, and I have prepared a list of all the episodes so far and the main topics.  This should help both new listeners and regulars to find episodes that pertain to particular topics.

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Dr. Robert Schleip Discusses Fascia on Books and Ideas

Books and Ideas Podcast #15 is an interview with Robert Schleip, PhD, from the University of Ulm in Germany.  Dr. Schleip is an experienced practitioner of the body work method known as Rolfing, but several years ago he went back and earned his PhD in Biology and began a second career as a research scientist.

In our interview, we discuss some of the recent discoveries that may revolutionize the way we look at the connective tissue that is commonly called fascia.  We also talk about the importance of applying the scientific method to the evaluation of alternative and complimentary healing methods (CAM).  Dr. Schleip's enthusiasm for science made this a very enjoyable interview.

References and Links:

Dr. Schleip recommends the Wikipedia entry on fascia if you would like to learn the basics.

To learn more about Dr. Schleip's work, visit the Fascia Research Project website at http://www.fasciaresearch.de/

The First International Congress International Research Congress was held in October, 2007 in Boston, MA.

You can find some of the scientists Dr. Schleip mentions this.

Click here for more references, including those written in German.

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Neuroplasticity with Dr. Norman Doidge (BSP 26)

Episode 26 of the Brain Science Podcast is an interview with Dr. Norman Doidge, MD, author of The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science (2007).  Dr. Doidge and I agree that neuroplasticity is the most important discovery about the brain that has been made in several hundred years.  In his interview, Dr. Doidge talks about some of the obstacles that delayed this discovery including what he calls the "plastic paradox," which is the fact that plasticity itself can contribute to the development of rigid behaviors, including addictions and bad habits.

The Brain That Changes Itself includes the work of the key scientists of neuroplasticity.  In my conversation with Dr. Doidge, we talked about the work of Paul Bach-y-Rita, Edward Taub, and VS Ramachandran.  Dr. Doidge also shared how his own work is being affected, and why he thinks neuroplasticity has the potential to lead to more important discoveries.

I will be talking to Dr. Taub in Episode 28.  If you are new to the Brain Science Podcast, you may want to go back and listen to Episode 10, which is where I first introduced neuroplasticity in my discussion of Train Your Mind, Change Your Brain: How a New Science Reveals Our Extraordinary Potential to Transform Ourselves, by Sharon Begley.

You can learn more about Dr. Doidge's work at his website: http://normandoidge.com

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Additional Show Notes for BSP 25

On the last episode of the Brain Science Podcast, I promised to list previous episodes that related to the discussion of embodied artificial intelligence.  For the sake of those of you who rely on the RSS feed to get the show notes, I am going to list those below. They have also been added to the original show notes.

Related Episodes of the Brain Science Podcast::Another thing I did not get into the original notes was a reference for the pivotal paper by Rodney Brooks. Here is  that reference:

Embodied Intelligence with Rolf Pfeifer (BSP 25)

How the Body Shapes the Way We Think, by Rolf Pfeifer and Josh Bongard

Brain Science Podcast  Episode 25 is an interview of author Rolf Pfeifer, director of the Artificial Intelligence Laboratory at the University of Zurich.  The focus of our conversation was the importance of embodiment.  Brains (and intelligence) cannot be understood separate from their interaction with the body and the physical world.  Pfeifer explains how this realization has led the field of artificial intelligence away from a pure computational approach to one he calls embodied artificial intelligence.  His interview is spiced with numerous examples that demonstrate why this approach is relevant to those of us who are interested in the human brain. 

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Episode Highlights:

  • A brief overview of artificial intelligence.

  • Introduction to biorobotics.

  • Why artificial intelligence and biorobotics are relevant to understand the brain.

  • The meaning of complexity and emergence.

  • Why the close coupling of the sensory and motor systems is essential to intelligence.

  • Applying design principles to understanding intelligence.

  • Numerous examples make these potentially intimidating topics accessible to all listeners.

  • I also introduced a new way for listeners to support the Brain Science Podcast 

Related episodes of the Brain Science Podcast:

Scientists mentioned in the podcast:

Books by Rodney Brooks:

Where to learn more about Pfeifer's work:

The Reading Brain (BSP 24)

Episode 24 of the Brain Science Podcast is a discussion of Proust and the Squid: The Story and Science of the Reading Brain, by Maryanne Wolf.

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Show Notes:

Dr. Wolf's book, Proust and the Squid: The Story and Science of the Reading Brain, is divided into three main topics: the history of how writing and reading developed over the last few thousand years, the developmental stages involved in learning how to read, and what happens when the brain can't learn to read.  My podcast concentrates on the main ideas from the first two topics.

History of Writing:

  • The discovery of symbols.

  • Early writing systems- cuneiform and hieroglyphics.

  • Why Chinese gives us a window into the past.

  • Importance of the alphabet.

  • Why Socrates opposed literacy.

The stages of becoming a reader:

  • The early pre-reader-with emphasis on language development.

  • The novice reader-connecting letters to the sounds of language.

  • The decoding reader.

  • The fluent comprehending reader-learning to "read between the lines."

  • The expert reader-why reading continues to change us throughout our lives.

  • What goes wrong when the brain can't learn to read: how new findings are leading to new solutions.

Links and References

  • Maryann Wolf, Director of the Center for Reading and Language Research at Tufts University.

  • Her book Proust and the Squid contains extensive references to various scientific studies in the area.

    1. information for teachers.

    2. interview of Dr. Wolf.

  • FastForward -a successful approach to treating dyslexia.

  • Michael Posner - a psychologist who used PET scans to study what happens during shifts of attention (a necessary first step in reading).

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Follow-up interview with Dr. Wolf (BSP 29)

Sandra Blakeslee (BSP 23)

This episode is an interview with Sandra Blakeslee, co-author (with her son Matthew) of The Body Has a Mind of Its Own: How Body Maps Help You Do (almost) Everything Better, which we discussed in Episode 21.

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Show Notes

I asked Blakeslee to tell me a little bit of her background as a science writer.  She wrote for the New York Times for many years and was the co-author of both Jeff Hawkins groundbreaking book, On Intelligenceand VS Ramachandran's modern classic Phantoms in the Brain (1998), which was one of the first books to explore neuroplasticity.

In this interview, we explored the relationship between body maps and neuroplasticity, as well as questions from listeners about out of body experiences and other oddities once considered "paranormal."  We talked about how body maps are relevant to understanding why some methods of alternative healing appear to be effective.

I asked her to tell me which scientist she met made the biggest impression.  Here are a few of those she mentioned:

Blakeslee told me about some of the pioneering work that Merzenich is doing to apply his discoveries to help people, both those with disabilities and those who just want to combat aging.  You can learn more about his work at http://www.positscience.com/.

If you would like to contact Sandra Blakeslee to give her feedback or ask her questions, she has a contact form on her books website at http://www.thebodyhasamindofitsown.com/.  She is going to let me know when she gets the references posted on the site.

Consciousness with Christof Koch (BSP 22)

Brain Science Podcast #22 is an interview with Dr. Christof Koch of Cal Tech, one of the pioneers in the neurobiological study of consciousness.  About two decades ago, when Koch and Francis Crick began looking for what they called the neural correlates of consciousness (NCC), such a quest was considered controversial; but now the field is increasing in popularity.  In our interview, we talked a little about his book,The Quest for Consciousness, as well as his on-going research and his thoughts about what the future might bring.

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Here is a list of some of the topics we discussed:

  • Why Francis Crick was an outstanding mentor and colleague.

  • A Working definition of consciousness.

  • How consciousness relates to awareness.

  • What are neural correlates of consciousness.

  • Why vision is the focus of Koch's research.

  • The search for the "footprints" of consciousness.

  • The role of functional imaging and the use of monkeys.

  • Neurons-"the atoms of perception".

  • Why we need a theory of consciousness.

  • The role of the frontal lobes in consciousness.

  • Is consciousness an emergent property?

  • What about zombies?

  • Why do we need consciousness?

  • Will artificial intelligence become conscious?

  • The hard problem:  how does the brain generate subjective experience  (qualia).

Links:

Update on 2012-05-03 15:42 by Ginger Campbell, MD

Christof Koch returned to the Brain Science Podcast in Episode 84.

A review of "The Body Has a Mind of Its Own" (BSP 21)

Featured in this episode: The Body has a Mind of Its Own: How Body Maps in Your Brain Help You Do (Almost) Everything Better (2007), by Sandra Blakeslee and Matthew Blakeslee.  (Also available on from Audible.com)

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SHOW NOTES

Topics:

  • Body maps and the role of embodiment.

  • Basic ideas about the body maps in the brain.

  • Mapping the world around us.

  • How body maps differ between species.

  • Body schema and body image.

  • The role of body maps in disease.

  • The role of belief in health and illness.

  • How body maps explain non-traditional healing methods and unusual experiences.

  • The role of motor imagery in improving motor skills.

  • Mirror Neurons and grid neurons in the hippocampus  (see more on Scholarpedia).

  • How sensation and emotions come together (the role of the insula).

Scientists mentioned in the podcast:

Other scientists mentioned in The Body has a Mind of Its Own:

Note: This list is not exhaustive.  I know I left off VS Ramachandran and several others, but those listed above did work that was addressed, directly or indirectly, in my podcast.

Brain Structures (links include diagrams of the brain):

"The Female Brain" with Dr. Louann Brizendine (BSP 20)

Episode 20 of the Brain Science Podcast is an interview with Dr. Louann Brizendine of the Women's Mood and Hormone Clinic at the University of California at San Francisco.   Her book, The Female Brainwas just released in paperback, and it is on the New York Times Bestseller list.

We explore how hormones and neurotransmitters effect our brains, and how these effects are different in men and women.  This episode has interesting stuff for listeners of both sexes.

If you would like to learn more, visit Dr. Brizendine's website at http://louannbrizendine.com.

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Review of "Gut Feelings" (BSP 19)

Show Notes forBrain Science Podcast #19: Gut Feelings

This episode is a discussion of Gut Feelings: The Intelligence of the Unconscious (2007), by Gerd Gigerenzer.

Dr. Gigerenzer argues that unconscious decision-making or intuition is actually based on the use of heuristics(rules of thumb) that can be explored, and even brought into awareness.  In this episode, I discuss his basic arguments with an emphasis on the differences between intuitive reasoning and formal logic.  Then we explore some examples including the application of these ideas to more controversial areas like morality and social instincts.

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References

Links of Interest:

Interview with Elkhonon Goldberg, PhD (BSP 18)

Episode 18 of the Brain Science Podcast is an interview with Dr. Elkhonon Goldberg, PhD.

Show Notes:

  • I apologize for the uneven sound quality of this episode.  If any one out there has any suggestions, please drop me an email.

  • Dr. Goldberg shared a little bit about the breadth of his work as a neuropsychologist.

  • We talked about his rather unique perspective on the difference between the right and left brain hemispheres.  He explained why he feels that as we get older we move from reliance on the right hemisphere, which he feels is the novelty hemisphere, to a reliance on the left hemisphere, where our lifetime store of patterns enables us to use pattern recognition as a short cut in problem solving.

  • We talked about the importance of constant mental challenge, and Dr. Goldberg gives his advice about how we can keep our brains healthy through out our lives.

Links:

The following are two companies that Dr. Goldberg is working with to provide information to the public and also tools for cognitive enhancement:

  • SharpBrains:  This is a clearing house for information, and they evaluate many of the products currently being offered.

  • HeadStrong Cognitive Fitness:  This Australian company offers a net-based program for cognitive enhancement based on Dr. Goldberg's research.  I am hoping to test their products in the near future.

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The Wisdom of the Aging Brain (BSP 17)

This week we discuss another book by Elkonon Goldberg, Ph.D.  I highly recommend this book to everyone, because it is an excellent review of many of the topics we have discussed over the last several months including memory, emotion, and neuroplasticity.   In this episode, we continue our discussion of the role of the pre-frontal lobes in intelligence, as well as what happens to our brain as we age.

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Show Notes

I want to thank Matthew Lofton for pointing out to me that there is evidence that elephants can recognize themselves in a mirror.  This means I was wrong when I said (in #16) that only humans and some primates can do this. He referred us to "I, Elephant," by Kaspar Mossmanin in the February 2007 issue of Scientific American Mind.  The original article was "Self-recognition in an Asian elephant," by:Plotnik, Joshua M.; de Waal, Frans B. M.; Reiss, Diana. Proceedings of the National Academy of Sciences of the United States of America, 11/7/2006, Vol. 103 Issue 45, p17053-17057.  He posted this information as a comment, but I wanted to bring this to everyone's attention.

Episodes that are referred to in this episode:

Note: You should have no problem listening to Episode #17 first, but I have provided these references for those who want to review or go back for more details.

Definitions used in this episode:

  • Attractor: a cognitive template that enables pattern recognition. An attractor is thought to be a concise set of neurons with strong interactions among themselves. A unique and important quality of attractors is that a broad range of inputs activate the same set of neurons. This is thought to be the mechanism of pattern recognition.

  • Cognitive competence: the ability to relate the old to the new so as to recognize the similarities between a new problem and one that has been previously solved.

  • Cognitive wisdom: an enhanced capacity for problem solving

  • Generic memory: memory for patterns

Brief list of topics discussed in this episode:

  • Review of important ideas about the prefrontal lobes from #16.

  • An hypothesis about the differing roles of the right and left hemispheres.

  • How the brain changes in normal aging.

  • Mechanisms that protect the brain from degenerative changes:

    • Generic memory-why this type of memory is more robust.

    • Pattern expansion-how parts of the cortex expand with use.

    • Effortless experts-why familiar tasks are less demanding.

    • Why vigorous mental activity is important throughout life.

For more links related to Dr. Goldberg's work see the show notes for Episode 16.

A review of "The Executive Brain" (BSP 16)

Brain Science Podcast #16 is a discussion of The Executive Brain: Frontal Lobes and the Civilized Mind (2002), by Elkhonon Goldberg.

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Show Notes

This episode is an introduction to the role of the pre-frontal lobes in decision-making, and the other "executive" functions of our brain.  The functions of the pre-frontal lobes are not only the keys to what makes us human, but also the keys to our individual personality.

In this episode, using Dr. Goldberg's book, we discuss how the frontal lobes relate to the other structures of the brain.  We also, discuss some ideas about why the left and right sides of the brain differ, as well as several important ways in which the cortex, and especially the pre-frontal lobes differ from some of the older parts of the brain.

We discuss briefly the vulnerability of the frontal lobes to damage and disease, and we consider the implications of frontal lobe dysfunction.  Questions are introduced that will be considered in more detail in future podcasts.

Links: