What Do Mirror Neurons Really Do? (BSP 112)

Greg Hickok, PhD (Click on photo to buy mp3)

Ever since their chance discovery back in 1992 mirror neurons have captured the imagination of both scientists and nonscientists, but their actual role remains mostly speculative. In The Myth of Mirror Neurons: The Real Neuroscience of Communication and Cognition Dr. Gregory Hickok (UC-Irvine) explains why the most popular theory is probably wrong. He also provides a fascinating account of how science is really done and the sobering lesson that scientists can fall prey to the same cognitive biases (and tendencies toward laziness) that plague all humans.

I first discussed the discovery of mirror neurons back in BSP 35 when I featured  Mirrors in the brain: How our minds share actions, emotions, and experience (2008) by Giacomo Rizzolatti and Corrado Sinigaglia. At that time what I found most fascinating was that since mirror neurons fire both when a subject (usually a monkey) performs an action and when a similar action is observed, this proves that single neurons are not necessarily purely motor or purely sensory. This surprising discovery seems to have been overshadowed in the rush to use mirror neurons to explain everything from autism to language evolution.

The latest Brain Science Podcast  (BSP 112) features an interview with Dr. Gregory Hickok. BSP 35 is also available for FREE via the Brain Science Podcast Mobile APP.

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References and Links

• Greg Hickok's Talking Brains blog

• The Myth of Mirror Neurons: The Real Neuroscience of Communication and Cognition by Gregory Hickok

• Mirrors in the brain: How our minds share actions, emotions, and experience (2008) by Giacomo Rizzolatti and Corrado Sinigaglia

• The Man Who Mistook His Wife for a Hat: and other Clinical Tales by Oliver Sacks

• See the episode transcript for additional references.

Related Episodes:

• BSP 35: introduction to Mirror Neurons (free as an episode extra if you use the BSP mobile app)

• BSP 39: Dr. Michael Arbib on the possible role of mirror neurons in language evolution (note this interview doesn't represent his current views)

Announcements:

• Next month's episode will provide exclusive coverage of "Neuroplasticity and Healing" an event being hosted by the Dalai Lama at the UAB School of Medicine.

• The most recent 25 episodes of the Brain Science Podcast are always FREE. Older episodes and episode transcripts are available for $1 each. Premium subscribers have unlimited access to all 100+ episodes and transcripts.

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Mirror Neurons with Michael Arbib (BSP 39)

Episode 39 of the Brain Science Podcast is an interview with Dr. Michael Arbib from the University of Southern California.  Dr. Arbib's work with functional brain imaging has established the presence of mirror neurons in the human brain.  In our interview, we focused on the role of mirror neurons in imitation and language.  In particular, I questioned Dr. Arbib about the Mirror System Hypothesis (MSH) of Language Evolution that he proposed in 1998 with Giacomo Rizzolatti.  We also explored how this hypothesis diverges from the universal grammar proposed by Noam Chomsky.  Dr. Arbib also shared his enthusiasm for future research and we talked about the special challenges caused by the interdisciplinary nature of modern neuroscience.

How to get this episode:

• Premium Subscribers now have unlimited access to all old episodes and transcripts.

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• New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Related Episodes:

• Brain Science Podcast  #7: A discussion of bonobos with Stuart Shanker, PhD.

• Brain Science Podcast  #30: a discussion of language evolution including my thoughts on Chomsky.

• Brain Science Podcast  #35: a detailed discussion of Mirrors in the Brain, by Giacomo Rizzolatti.

Scientists mentioned in the interview:

• Giacomo Rizzolatti: His team discovered mirror neurons at the University of Parma, Italy. Other team members: Vittorio Gallese, Luciano Fadiga, and Leo Fogassi.

• Ursula Bellugi (Salk Institute): pioneered the neurobiology of sign language.

• Richard Byrne (University of St. Andrews): studies how gorillas learn in the wild.

• Michael Tomasello (Max Planck Institute for Comparative Anthropology): studies social behavior of primates, including how communicative gestures vary between groups.

• Noam Chomsky (MIT): famous linguist who has proposed an inborn universal grammar.

• DL Cheney and RM Seyfarth:  research about primate vocal behavior, especially the use of calls in the wild.

References:

• Cybernetics, by Norbert Wiener- this classic inspired Dr. Arbib's career in computational neuroscience.

• Action to Language via the Mirror Neuron System, (2006) edited by Michael Arbib.

• Mirrors in the Brain by Giacomo Rizzolatti and Corrado Sinigaglia, 2008. Discussed in Episode 37.

• Mirroring People by Marco Iacoboni, 2008.  The author studies mirror neurons at UCLA.

• Rizzolatti G & Arbib MA  Language within our grasp. Trends in Neuroscience 21(5): 188-194- the first paper describing the Mirror System Hypothesis, 1998.

• Iacoboni M, Molnar-Szakacs I, Gallese V, Buccino G, Mazziotta JC, et al.  Grasping the intentions of others with one's own mirror neuron system. PLoS Biol 3 (3): e79, 2005.

• Arbib, M.A., "From Monkey-like Action Recognition to Human Language: An Evolutionary Framework for Neurolinguistics"  (with commentaries and author’s response), Behavioral and Brain Sciences, 28:105-167.  (Click here for supplemental commentaries and the author’s “electronic response.”) 2005.

• Arbib MA 2006 "Broca's Area in System Perspective: Language in the Context of Action-Oriented Perception" in Broca's Region, Oxford University Press, pp 153-168.

• Arbib MA 2008 "Invention and Community in the Emergence of Language: Insights from New Sign Languages," in Foundations in Evolutionary Cognitive Neuroscience, Cambridge University Press.

• Click here for more papers by Dr. Arbib.  He has also written over 40 books.

Other Links:

• Michael Arbib's website.

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A Closer Look at Mirror Neurons (BSP 35)

Brain Science Podcast #35 is a discussion of Mirrors in the Brain: How Our Minds Share Actions, Emotions, and Experience, by Giacomo Rizzolatti and Corrado Sinigaglia.  Mirror neurons were discovered in Rizzolatti's lab in Parma, Italy, in the early 1990s, and his book is a detailed to discussion of the experimental evidence in both monkeys and humans.  Direct single neuron recordings have been made in monkeys.  The evidence in humans is indirect, since it is based on mainly on neuro-imaging studies like PET scans and fMRI scans.  Even so, mirror neurons appear to be essential to our ability to understand both the actions and emotions of others. 

In this episode, we also explore the evidence that there are other neurons in the motor areas of the brain that have sensory properties and that the areas of the brain traditionally thought to be devoted to sensory functions also contain neurons with motor properties.  Another fascinating discovery is the fact that there are neurons that respond not only to somatosensory inputs (such as being touched) but also to visual or auditory inputs from objects within our peri-personal space.  For background on these body maps, I recommend listening to Episode 21 and Episode 23.  If you are new to the Brain Science Podcast, you may want to listen to those episodes first, because this week's episode is a little more technical than most.

I will be exploring the importance of these discoveries in future episodes.

How to get this episode:

• Premium Subscribers now have unlimited access to all old episodes and transcripts.

• Buy mp3 for $1.

• Buy Transcript for $1.

• New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Links:

• Giacomo Rizzolatti: University of Parma.

• Mirror neurons (Wikipedia entry).

• Mirror neurons  (Scholarpedia entry written by Dr. Rizzolatti),

Donations and Subscriptions are appreciated

A review of "The Body Has a Mind of Its Own" (BSP 21)

Featured in this episode: The Body has a Mind of Its Own: How Body Maps in Your Brain Help You Do (Almost) Everything Better (2007), by Sandra Blakeslee and Matthew Blakeslee.  (Also available on from Audible.com)

How to get this episode:

• Premium Subscribers now have unlimited access to all old episodes and transcripts.

• Buy mp3 for $1.

• Buy Transcript for $1.

• New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

SHOW NOTES

Topics:

• Body maps and the role of embodiment.

• Basic ideas about the body maps in the brain.

• Mapping the world around us.

• How body maps differ between species.

• Body schema and body image.

• The role of body maps in disease.

• The role of belief in health and illness.

• How body maps explain non-traditional healing methods and unusual experiences.

• The role of motor imagery in improving motor skills.

• Mirror Neurons and grid neurons in the hippocampus  (see more on Scholarpedia).

• How sensation and emotions come together (the role of the insula).

Scientists mentioned in the podcast:

• Wilder Penfield:  Discovered the maps of the primary sensory and primary motor cortex.

• Sir Henry Head and Gordon Holmes:  British neurologists who first proposed the idea of the body schema in 1911.

• Arthur Craig:  First to study the unique wiring of the insula.

• Antonio Damasio: studies the role of emotion in intelligent decision-making.

• Marco Iacoboni:  Demonstrated the role of the right angular cingulate gyrus in our sense of self versus others.  (Dr. Iacoboni has PDF's available on his site).

Other scientists mentioned in The Body has a Mind of Its Own:

• William Straub: Sports psychologist who demonstrated that students could improve at darts through mental imagery.

• Alvaro Pascual-Leone:  Used 5 finger piano exercise to show changes in motor maps both from actual practice and from imagery.

• Michael Merzenich:  Classic experiments showing changing in motor maps in monkeys.

• Scott Frey:  Using imagery in stroke rehab.

• Jennifer Stevens:  Use of mirror boxes in stroke rehab.

• Edoardo Bisiach:  Theories about spatial awareness and neglect.

• Jamie Ward:  Documented a patient with color-emotion synesthesia as possible explanation for auras.

• Olaf Blanke:  Studies the anterior cingulate gyrus, which map be important in out-of-body experiences.

• Atsushi Iriki:  Has demonstrated how the parietal lobes in monkeys change with tool use.

• Christian Keysters:  Thinks mirror neurons may be a key precursor for the development of abstract thought and language

• Hugo Critchley:  Expert in brain imaging who is interested in the relationship between emotional intelligence and interoception (visceral awareness).

• John Allman:  Studies the role of the frontal insula and anterior cingulate gyrus in intuition (quick decisions).

• Sara Lazar:  Has demonstrated that the right frontal insula and left prefrontal cortex increase in size in experienced meditators.

Note: This list is not exhaustive.  I know I left off VS Ramachandran and several others, but those listed above did work that was addressed, directly or indirectly, in my podcast.

Brain Structures (links include diagrams of the brain):

• Primary Sensory Cortex.

• Primary Motor Cortex.

• Premotor Cortex.

• Frontal Insula.

• Parietal lobe.

• Amygdala.

• Anterior Cingulate Gyrus.