Sleep Science with Penny Lewis (BSP 107)

Penny Lewis

In The Secret World of Sleep: The Surprising Science of the Mind at Rest Dr. Penelope A. Lewis provides a highly readable account of the fascinating world of sleep research. Fascinating research is being carried out with animals as varied as fruit flies and rats, as well as with humans. I was surprised to learn that most people actually find it fairly easy to fall asleep in an fMRI scanner.

I have just posted an interview with Dr. Lewis (BSP 107) that includes a discussion of the role of sleep in memory as well as interesting findings about how synapses in the brain actually change during sleep. We still don't know exactly what sleep (and dreaming) are essential, but research in this field is growing. Dr. Lewis is excited about emerging research that suggests improving slow wave sleep may significantly improve learning and memory.

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References:

• The Secret World of Sleep: The Surprising Science of the Mind at Rest by Penelope A. Lewis

• Dreamland: Adventures in the Strange Science of Sleep by David K. Randall (audible link)

• Dreaming: A Very Short Introduction by J. Allan Hobson

• Xie L, Kang H, Xu Q, et.al. 2013. Sleep Drives Metabolite Clearance from the Adult Brain. Science 342: 373-377. DOI: 10.1126/science.1241224 http://www.ncbi.nlm.nih.gov/pubmed/?term=Sleep+Drives+Metabolite+Clearance+from+the+Adult+Brain

• G. Tononi and C. Cirelli, “Sleep and Synaptic Homeostatis: A Hypothesis,” Brain Res. Bull. 62 (2003): 143-150. http://www.ncbi.nlm.nih.gov/pubmed/14638388

• Bushey D, Tononi G, Cirelli C. Sleep and synaptic homeostasis: structural evidence in Drosophila. Science, 332(6037):1576-1581, 2011. [DOI: 10.1126/science.1202839]. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715914/

• See episode transcript for additional links and references.

Announcements:

• Dr. Campbell has been invited to speak at The Amazing Meeting 2014, which will be held in Las Vegas July 10-13. This year's theme is Skepticism and The Brain. Stay tuned to learn more.

• It will soon be possible to gain CE credit for selected episodes of the Brain Science Podcast.

• Listener John Richards has relaunched is excellent Neuroscience Glossary at http://richardsonthebrain.com. This is a great place to learn more about terms and ideas that you hear on the Brain Science Podcast.

• Please post your comments about this episode in our Goodreads Group at http://brainscienceforum.com or send email to brainsciencepodcast@gmail.com.

Brain Plasticity with Michael Merzenich (BSP 105)

Michael Merzenich

If you have read anything about brain plasticity you have seen the name Michael Merzenich. Dr. Merzenich is one of the pioneers in this field, having spent over 30 years documenting that the human brain (and that of other mammals) continues to change throughout life. I interviewed Dr. Merzenich several years ago (BSP 54), but the publication of his first book Soft-Wired: How the New Science of Brain Plasticity Can Change Your Life gave us another opportunity to talk about how we can apply these discoveries in our daily lives.

According to Dr. Merzenich, "No matter how much you've struggled, no matter where you've been in your life, you're in charge of your life going forward.  And you have the capacity; you have the resources to change things for the better—always have that capacity.  And that's what the book is trying to emphasize. “ (BSP 105)

I found Soft-wired very compelling because it combines a clear explanation of the science with many stories about real people facing a wide variety of cognitive challenges. The overall tone of the book is very optimistic even though it also considers the way bad choices can contribute to cognitive decline. 

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Related Episodes:

• BSP 10: Introduction to Brain Plasticity.

• BSP 17: Discussion of The Wisdom Paradox: How Your Mind Can Grow Stronger As Your Brain Grows Older by Elkhonon Goldberg.

• BSP 28: Interview with Dr. Norman Doidge, author of The Brain That Changes Itself.

• BSP 33: Interview with Dr. John Ratey, author of Spark: The Revolutionary New Science of Exercise and the Brain.

• BSP 54: Interview with Dr. Michael Merzenich, author of Soft-wired.

• BSP 87: Interview with Dr. Pam Greenwood, co-author of Nurturing the Older Brain and Mind.

Further Reading:

• Soft-Wired: How the New Science of Brain Plasticity Can Change Your Life by Dr. Michael Merzenich PhD. References for this book can be found at http://www.soft-wired.com/ref/.

• The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science, by Norman Doidge.

• Nurturing the Older Brain and Mind by Pamela M. Greenwood and Raja Parasuraman.

• Spark: The Revolutionary New Science of Exercise and the Brain by John J. Ratey.

• The Wisdom Paradox: How Your Mind Can Grow Stronger As Your Brain Grows Older by Elkhonon Goldberg.

• Train Your Mind, Change Your Brain: How a New Science Reveals Our Extraordinary Potential to Transform Ourselves by Sharon Begley (featured in BSP 10).

Celebrating 4 Years of the Brain Science Podcast (BSP 71)

The latest episode of the Brain Science Podcast (BSP 71) is our 4th annual review episode.  As usual, I review highlights from this year's interviews, but this year I added a new feature: my personal reflections on how the Brain Science Podcast has impacted my life.  This episode also contains a special announcement for UK listeners.

How to get this episode:

• Buy mp3 for $1.

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• Premium Subscribers have unlimited access to ALL old episodes and transcripts, as well as extra content for selected episodes. All content is available browser or the free Brain Science mobile app.

• Patreon supporters have access to new transcripts ($3+/month) and ad-free audio files ($10+/month). You can also access your bonus content via the free Patreon mobile app.

  New episodes of Brain Science are ALWAYS FREE and remain FREE for approximately 6 years. See the individual show notes for more information

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Major Topics from Season 4:

• Emotions with Jaak Panksepp (BSP 65).

• Memory with Randy Gallistel (BSP 66).

• Consciousness with Thomas Metzinger (BSP 67).

• Alzheimer's Disease with Peter Whitehouse (BSP 68 and Books and Ideas 36).

• Glia Cells with R. Douglas Fields (BSP 69).

• Pop Psychology Myths with Scott Lilienfeld (BSP 70).

References:

• Affective Neuroscience: The Foundations of Human and Animal Emotions, by Jaak Panksepp (BSP 65).

• Memory and the Computational Brain: Why Cognitive Science will Transform Neuroscience, by C. R. Gallistel, Adam Philip King (BSP 66).

• The Ego Tunnel: The Science of the Mind and the Myth of the Self,by Thomas Metzinger (BSP 67)

• The Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis, by Peter J. Whitehouse and Daniel George (BSP 68 and Books and Ideas 36).

• The Other Brain: From Dementia to Schizophrenia, How New Discoveries about the Brain Are Revolutionizing Medicine and Science, by R. Douglas Fields (BSP 69).

• 50 Great Myths of Popular Psychology: Shattering Widespread Misconceptions about Human Behavior, by Scott O. Lilienfeld, Steven Jay Lynn, John Ruscio, Barry L. Beyerstein (BSP 70).

• For additional references: follow links to episode show notes.

Announcements:

• The Brain Science Podcast app is now available for both iPhone and ANDROID (NEW!)

• Be sure to subscribe to my Books and Ideas podcast. The next episode will come out in December.

• The next episode of the Brain Science Podcast will come out in January 2010. 

Send me feedback at brainsciencepodcast@gmail.com.

Pop Psychology Myths with Scott Lilienfeld (BSP 70)

BSP 70 is an interview with Dr. Scott Lilienfeld, co-author of 50 Great Myths of Popular Psychology: Shattering Widespread Misconceptions about Human Behavior.  This episode was recorded live at Dragon*Con 2010 in Atlanta, Georgia.  We focused our conversation on the fact that scientific reasoning and critical thinking do NOT come naturally; instead, we all tend to make similar errors, such as mistaking correlation for causation.  Dr. Lilienfeld shared his experiences, and an extensive question and answer session with the live audience allowed him to explore additional examples.

How to get this episode:

• Buy mp3 for $1.

• Buy Transcript for $1.

• Premium Subscribers have unlimited access to ALL old episodes and transcripts, as well as extra content for selected episodes. All content is available browser or the free Brain Science mobile app.

• Patreon supporters have access to new transcripts ($3+/month) and ad-free audio files ($10+/month). You can also access your bonus content via the free Patreon mobile app.

  New episodes of Brain Science are ALWAYS FREE and remain FREE for approximately 6 years. See the individual show notes for more information

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Connect on Social Media:

• Twitter: @docartemis

• Facebook page: http://www.facebook.com/brainsciencepodcast

Contact Dr. Campbell:

• Email: brainsciencepodcast@gmail.com

Memory: Challenging Current Theories with Randy Gallistel, PhD (BSP 66)

Episode 66 of the Brain Science Podcast is an interview with Randy Gallistel, PhD, Co-Director of the Rutgers Center for Cognitive Science and co-author (with Adam Philip King) of Memory and the Computational Brain: Why Cognitive Science Will Transform Neuroscience.

We discuss why read/write memory is an essential element of computation, with an emphasis on the animal experiments that support the claim that brains must possess read/write memory.  This is significant because current models, such as neural nets, DO NOT incorporate read/write memory in their assumptions about how brains work.  It is not necessary to have any background in information theory or computation to appreciate the experiments that are discussed in this episode.

Episode 3 and Episode 12 of the Brain Science Podcast  providebackground information for this episode.

How to get this episode:

• Premium Subscribers now have unlimited access to all old episodes and transcripts.

• Buy mp3 for $1.

• Buy Transcript for $1.

• New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References and Links:

• Spikes: Exploring the Neural Code, by Fred Rieke, David Warland, Rob de Ruyter van Steveninck, William Bialek.

• Memory and the Computational Brain: Why Cognitive Science Will Transform Neuroscience, by C. R. Gallistel, Adam Philip King.

• Claude E. Shannon:  His paper (A Mathematical Theory of Communication, Bell System Technical Journal, Vol. 27, pp. 379–423, 623–656, 1948) is a cornerstone of information theory.

• Rüdiger Wehner: Swiss researcher who has studied dead reckoning in insects.

• Nicky Clayton and Tony Dickinson: these researchers have performed elegant experiments that study scrub jay caching.

• Christof Koch: was interviewed in Episode 22 of the Brain Science Podcast.

Announcements:

• This was Dr. Campbell's 100th podcast (BSP 66 plus Books and Ideas 34)! How long have you been listening?

• Please sign up for the Brain Science Podcast  Newsletter

• If you have an iPhone® or iPod Touch® check out the BSP application in the iTunes® Store.

Send feedback to gincampbell at mac dot com or leave voice mail at 205-202-0663.

Michael Merzenich Talks About Neuroplasticity (BSP 54)

Brain Science Podcast #54 is an interview with Dr. Michael Merzenich, one of the pioneers of neuroplasticity.  We talk about how the success of the cochlear implant revealed unexpected plasticity in adult brains and about how brain plasticity can be tapped to improve a wide variety of problems including dyslexia, autism, damage from disease and injury.  Healthy people of all ages can also tap the resource of brain plasticity to help maintain and improve their mental functions.

How to get this episode:

• Premium Subscribers now have unlimited access to all old episodes and transcripts.

• Buy mp3 for $1.

• Buy Transcript for $1.

• New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Links and References

• Dr. Merzenich's Blog.

• Posit Science Corporation.

• Scientific Learning (Fast Forward™).

Previous Episodes on Brain Plasticity

• Episode 10.

• Episode 26.

• Episode 28.

Send email feedback to Ginger Campbell, MD at brainsciencepodcast@gmail.com

Dr. Brenda Milner: Pioneer in Memory Research (BSP 49)

Brain Science Podcast #49 is an interview with pioneering neuroscientist, Brenda Milner, PhD.  Dr. Milner is known for her contributions to understanding memory and her work with split-brain patients.  Her work as an experimental psychologist has been fundamental to the emergence of the field of cognitive neuroscience.

This interview is a follow-up of Dr. Milner's recent interview with Dr. Marc Pelletier on Futures in Biotech.  I highly recommend listening to both interviews.

How to get this episode:

• Premium Subscribers now have unlimited access to all old episodes and transcripts.

• Buy mp3 for $1.

• Buy Transcript for $1.

• New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Listen to Dr. Milner on Futures in Biotech (Episode33)

Additional Links:

• Brenda Milner, PhD: Montreal Neurological Institute.  (Read her MNI biography)

• Wilder Penfield, MD: neurosurgeon and found of the Montreal Neurological Institute.

• Roger Sperry, PhD: received the Nobel Prize for his work with split-brain patients

Send email feedback to Ginger Campbell, MD at brainsciencepodcast@gmail.com.

"On Being Certain": Interview with Robert Burton, MD (BSP 43)

BSP 43 is an interview with Robert A Burton, MD, author of On Being Certain: Believing You Are Right Even When You're Not. This is a follow up to BSP 42.

How to get this episode:

• Premium Subscribers now have unlimited access to all old episodes and transcripts.

• Buy mp3 for $1.

• Buy Transcript for $1.

• New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Other scientists/writers mentioned in this episode:

• Benjamin Libet: important experiments showing that unconscious signals precede our awareness of deciding to act.

• Timothy Wilson: Strangers to Ourselves.

• John Searle, philosopher: Mind: A Brief Introduction.

• David Bohm, physicist:Thought as a System.

Other terms mentioned in the interview:

• Cotard's Syndrome: when the patient believes they do not exist or that they are dead

• Cognitive dissonance: a mismatch between what one believes and what the evidence supports

Previous Episodes of the Brain Science Podcast:

• Episode 42: Part 1 of our discussion of On Being Certain.

• Episode 13: Unconscious Decisions-featuring Blink, by Malcom Gladwel.l

• Episode 15: Interview with Read Montague about unconscious decisions.

Donations and Subscriptions are appreciated

Send email feedback to Ginger Campbell, MD at brainsciencepodcast@gmail.com

Don't Miss Neuroscience Pioneer, Dr. Brenda Milner, on Futures in Biotech

In Episode 33 Futures in Biotech  host Marc Pelletier, PhD, interviews pioneering researcher, Dr. Brenda Milner from the Montreal Neurological Institute.  Dr. Milner is best known for her work with HM, the patient that she worked with for many decades.  Her work helped neuroscientists appreciate the role of the hippocampus in memory and the fact that there are multiple types of memory, some of which do not require the hippocampus.

One of the things that makes this interview special is that Dr. Milner gives us the inside story on some of the pioneering work that we now take for granted.  She emphasizes how the work fit into the context of its time, giving an unique glimpse into the history of how science really unfolds.

Click here to learn more.

Futures in Biotech is a valuable contributor to SCIENCEPODCASTERS.ORG.

Review: "On Being Certain" (BSP 42)

Episode 42 of the Brain Science Podcast is a discussion of On Being Certain: Believing You Are Right Even When You're Not, by Robert Burton, MD.  This Part 1 of a two-part discussion of the unconscious origins of what Dr. Burton calls "the feeling of knowing."  In Episode 43 I will interview Dr. Burton. Today's episode provides an overview of Dr. Burton's key ideas.

In past episodes I have discussed the role of unconscious decision-making.  On Being Certain: Believing You Are Right Even When You're Not ,by Robert Burton, MD, takes this topic to a new level.  First, Dr. Burton discusses the evidence that the "feeling of knowing" arises from parts of our brain that we can neither access or control.  Then he discusses the implications of this finding, including the fact that it challenges long-held assumptions about the possibility of purely rational thought.

How to get this episode:

• Premium Subscribers now have unlimited access to all old episodes and transcripts.

• Buy mp3 for $1.

• Buy Transcript for $1.

• New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

References and Links:

• On Being Certain: Believing You Are Right Even When You're Not, by Robert Burton, MD.

• Robert Burton's website.

• Neisser, U., and Harsh, N. "Phantom Flashbulbs: False Recollections of Hearing the News about Challenger,"  in Affect and Accuracy in Recall: Studies of "Flashbulb" Memories, Winograd, E., and Neisser, U., (New York: Cambridge University Press, 1992).

• The Seven Sins of Memory: How the Mind Forgets and Remembers, by Daniel L. Schacter.

• The Feeling of What Happens: Body and Emotion in the Making of Consciousness, by Antonio Damasio.

• Philosophy in the Flesh : The Embodied Mind and Its Challenge to Western Thought by George Lakoff and Mark Johnson.

Other scientists mentioned in this episode:

• Leon Festinger-proposed the theory of cognitive dissonance in 1957.

• Joseph Ledoux-research with rats and the role of the amygdala in the fear response.

• Michael Merzenich-showed how the auditory cortex in young rats is affected by experience.

Donations and Subscriptions are appreciated

Send email feedback to Ginger Campbell, MD at brainsciencepodcast@gmail.com

Taking Tests Might Help Your Memory!

There is an interesting paper in this week's Science magazine that suggests that being tested might be an essential component of making what we study part of longterm memory.  In the study, students had memorize Swahili-English word pairs.  According to the authors,"Repeated studying after learning had no effect on delayed recall, but repeated testing produced a large positive effect."

"The Critical Importance of Retrieval for Learning," by Jeffrey D. Karpicke and Henry L. Roediger, III2, Science 15 February 2008: Vol. 319. no. 5865, pp. 966 - 968

Year-end Review for 2007 (BSP 27)

Episode 27 is a look back on the first 26 episodes of the Brain Science Podcast.

I look back on some of the main topics that we have explored including memory, consciousness, emotions, decision-making, body maps, and plasticity.  Then I talk a little about what I hope to do in the covering year.  This episode is a little more personal than most, and will mainly be of interest to regular listeners.  It includes some ideas about how you can help the Brain Science Podcast grow and prosper.

However, in preparing this episode, I went back over the past year's episodes, and I have prepared a list of all the episodes so far and the main topics.  This should help both new listeners and regulars to find episodes that pertain to particular topics.

How to get this episode:

• Premium Subscribers now have unlimited access to all old episodes and transcripts.

• Buy mp3 for $1.

• Buy Transcript for $1.

• New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Eric Kandel Talks About Memory on Futures in Biotech

The latest episode of Futures in Biotech (FiB 20) is an interview with Dr. Eric Kandel, who won a Nobel Prize in 2000 for his discoveries about how memory works.  I think you will enjoy listening to Dr. Kandel's interview.

I discussed Dr. Kandel's book, In Search of Memory, in Episode 3 of the Brain Science Podcast.  I also discussed his textbook, Memory: From Mind to Molecules in Episode 12.

For anyone who would like to go back and listen to these episodes, I have provided direct links to the audio files below:

#3: In Search of Memory

#12: Memory: From Mind to Molecules