Brain Networks with Olaf Sporns (BSP 74)

/
Olaf.jpg

Networks of the Brain by Olaf Sporns is an excellent comprehensive introduction to the use of Network Theory to study both the brain and the nervous systems of invertebrates.

In Episode 74 of the Brain Science Podcast, I interviewed Dr. Sporns (Indiana University) about some of the key ideas in his book.  Network Theory is becoming increasingly important as a tool for dealing with the massive amounts of data being generated by current techniques, such as brain imaging.  It is also a valuable tool for dealing with the fact that nervous systems consist of multiple scales (from the molecular level up to billions of neurons), which can not be reduced to a single scale.

While Networks of the Brain will be of greatest interest to those working in neuroscience and to those with a background in fields like engineering, mathematics, and computer science, this interview provides an introduction for listeners of all backgrounds.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Links:

References:

Related Episodes:

  • BSP 31: Interview with György Buzsáki, author of Rhythms of the Brain.

  • BSP 46: Discussion of Brain Imaging, including Diffusion Imaging.

  • BSP 56: Interview with Dr. Eve Marder about the use of circuit theory in neuroscience.

  • BSP 61: Mapping the Brain (and generating huge amounts of data).

Announcements:

The Brain Science Podcast app is available for iPhone, Android, and iPad. If you have purchased the iPhone version, it will now work on your iPad (no additional purchase needed). The iPad is the perfect device for reading episode transcripts, especially if you want to read along as you listen.

Contact Dr. Campbell:

  • Send Dr. Campbell email at brainsciencepodcast@gmail.com.

Embodied Cognition with Lawrence Shapiro (BSP 73)

/
Shapiro.jpg

In his new book, Embodied Cognition, Dr. Lawrence Shapiro provides a balanced introduction to embodied cognition's attempts to challenge standard cognitive science.  His interview in Episode 73 of the Brain Science Podcast is a discussion of a few of his book's key ideas. It also continues our ongoing exploration of the role of embodiment. 

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Related Episodes:

  • BSP 25: Embodied Artificial Intelligence with Dr. Rolf Pfeifer.

  • BSP 36: Introduction to Embodied Cognition with Dr. Art Glenberg.

  • BSP 58: "Extended Mind" with philosopher Alva Noë.

  • BSP 66: Computational cognitive science with Dr. Randy Gallistel.

Some scientists mentioned in this episode:

References:

Announcements:

Send feed back to Dr. Campbell at brainsciencepodcast@gmail.com

Magic and the Brain (BSP 72)

/
smc_lab.jpg

Dr. Susana Martinez-Conde

Neuroscientists Dr. Stephen Macknik and Dr. Susana Martinez-Conde have an unusual hobby: Magic!  Actually, it is more than a hobby since for the last several years they have been working with leading magicians from around the world to create a new field: the neuroscience of magic.  In Episode 72 of the Brain Science Podcast, I talked with them about their new book Sleights of Mind: What the Neuroscience of Magic Reveals about Our Everyday Deceptions, which is the first book to explore the neuroscience of magic.

DrMacknik3377.jpg

With the help of their co-author Sandra Blakeslee, Macknik and Martinez-Conde provide an excellent overview of this new and exciting field.  Their book also provides an excellent review of many of the principles that I have introduced in the last 4 years.

How to get BSP 72:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

 Links and References

Scientists mentioned during the podcast

Magicians mentioned during the interview

Announcements:

Send me feedback at brainsciencepodcast@gmail.com.

Exploring Glial Cells with R. Douglas Fields (BSP 69)

/

Recent research has discovered that glial cells (the non-neuronal cells that make up about 85% of the cells in the human nervous system) actually do more than just support neurons.  In Episode 69 of the Brain Science Podcast, I explore some of these recent discoveries with pioneering researcher, R. Douglas Fields, PhD.  Dr. Fields is the author of The Other Brain: From Dementia to Schizophrenia, How New Discoveries about the Brain Are Revolutionizing Medicine and Science.  The Other Brain provides a compelling introduction to this exciting new field.  It is aimed at general readers, but it should also be on the must-read list for all students of neuroscience.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

  • The Other Brain: From Dementia to Schizophrenia, How New Discoveries about the Brain Are Revolutionizing Medicine and Science, by R. Douglas Fields (2010).

  • Glial Neurobiology: A Textbook, by Alexei Verkhratsky and Arthur Butt (2007).

  • Bullock, T. H., Bennett, M. V., Johnston, D., Josephson, R., Marder, E., Fields, R. D. "Neuroscience. The neuron doctrine, redux." Science 310. 5749 (2005): 791-3.

  • Perspectives.

  • Bullock, T. H. (2004) The Natural History of Neuroglia: an agenda for comparative studies. Neuron Glial Biology 1:97-100.

  • Fields, R. D. (2006) Beyond the Neuron Doctrine. Scientific American Mind June/July 17:20-27.

Links:

  • The Other Brain website.

  • R. Douglas Fields: Chief and Senior Researcher of the Section on Nervous System Development and Plasticity at the National Institute of Child Health and Human Development, which is part of NIH.

  • Dr. Ichiji Tasaki; worked at NIH for over 50 years and was a pioneering researcher of nerve conduction. (See the episode transcript for links to the other researchers that were mentioned in this episode.)

Related Episodes of the Brain Science Podcast:

  • BSP 8: How Neurons Communicate.

  • BSP 56: Interview with Dr. Eve Marder

Announcements:

  • The Brain Science Podcast application for iPhone/Touch now contains transcripts for all episodes.  Your reviews are greatly appreciated.

  • The next new episode of the Brain Science Podcast will come out in September, 2010.

  • Be sure to check out my other podcast Books and Ideas.

  • For more science podcasts go to http://sciencepodcasters.org.

  • Stay informed by subscribing to the BSP Newsletter.

  • Correction: Barbara Strauch is the author of The Secret Life of the Grown-up Brain: The Surprising Talents of the Middle-Aged Mind.  (Note the correct spelling of STRAUCH)

Send me feedback at brainsciencepodcast@gmail.com.

Alzheimer's Disease with Dr. Peter Whitehouse (BSP 68)

/

Brain Science Podcast 68 is an interview with Dr. Peter Whitehouse, co-author (with Daniel George) ofThe Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis.  Alzheimer's Disease originally referred to a relatively rare form of premature dementia, but in recent decades the diagnosis has been expanded to include patients of all ages. This change is not based on science, and in this interview we talk about why being labeled with with Alzheimer's may be doing older patients more harm than good.

Dr. Whitehouse is one of the pioneering researchers in this field, but advocates devoting resources to helping elders with with a wide range of age-related brain changes.  This interview should be of interest to physicians, scientists, as well as patients and their families.  I will be posting a supplemental interview with Daniel George, the co-author of The Myth of Alzheimer's later this month.  (Learn more at http://booksandideas.com)

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Links:

Announcements:

  • Subscribe to the Books and Ideas podcast to get the extra interview with Daniel George.

  • The Brain Science Podcast iPhone application also works on the new iPad, but we are having to re-upload our old episode transcripts.

  • Don't forget you can get show notes to each episode automatically if you subscribe to the Brain Science Podcast   Newsletter.

  • This podcast is supported by listener donations.

Send feedback to brainsciencepodcast@gmail.com.

Thomas Metzinger Explores Consciousness (BSP 67)

/

The free podcast version of Brain Science Podcast 67 is now available.  It is an interview with German philosopher Thomas Metzinger, author of The Ego Tunnel: The Science of the Mind and the Myth of the Self , and Being No One.   Dr. Metzinger argues that any credible model for how the brain generates the mind must incorporate unusual human experiences, such as so-called out of body experiences (OBE), and psychiatric conditions.  In this interview we explore how OBE and virtual reality experiments shed light on how the brain generates the sense of self that characterizes normal human experience.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Links:

Related Episodes of the Brain Science Podcast:

References:

Announcements:

  • BSP 68 will be an interview with geriatric neurologist, Peter Whitehouse, author of The Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis.  The premium version will be available on April 1 and will include an additional interview with his co-author Daniel George.  The free podcast will come out the second week of April.  

  • The latest episode of my Books and Ideas podcast is an interview with best-selling horror writer Scott Sigler.  We discuss the challenges of incorporating accurate science into fiction writing. (Listen to the end to get a coupon code for his book The Rookie.) 

  • Read episode transcripts right on your iPhone® or Touch® with the BSP application.

  • Get episode show notes automatically via the free Brain Science Podcast Newsletter.

  • Leave your feedback in the Discussion Forum or on our Facebook Fan Page or send email to brainsciencepodcast@gmail.com.

"SuperSense": Bruce Hood on Believing the Unbelievable

/

Episode 34 of Books and Ideas  is an interview with Bruce M Hood, author of SuperSense: Why We Believe in the Unbelievable .

Dr. Hood is a developmental psychologist with a long-standing interest in why people believe weird things.  In SuperSense, he argues that innate cognitive structures (how we think without being taught) give people a natural tendency toward belief in the supernatural.  Our intuitive sense of how the world works is often at odds with the findings of modern science.

In this interview we discuss the evidence for these conclusions and their implications.

Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Click here for detailed show notes and to learn more about more free episodes of Books and Ideas.

Affective Neuroscience with Jaak Panksepp (BSP 65)

/

Episode 65 of the Brain Science Podcast is an interview with Jaak Panksepp, PhD, author of Affective Neuroscience: The Foundations of Human and Animal Emotions.   Dr. Panksepp has done pioneering work on the neural origins of emotions.   In this interview, we discuss how his work challenges some of the common assumptions about emotions and some of the important implications of his discoveries.  New listeners may want to go back and listen to Episode 11 for an introduction to the neuroscience of emotion.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Scientists Mentioned in this Episode:

Send feedback to brainsciencepodcast@gmail.com.

Reviewing Year 3 of the Brain Science Podcast (BSP 64)

/

Episode 64 of the Brain Science Podcast  is our Third Annual Review Episode.  It includes a review of some of the major ideas we talked about in 2009 and a look ahead to what I have planned for 2010.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Main Books Discussed in 2009:

Guests who appeared on the Brain Science Podcast in 2009:

  • David Bainbridge, PhD: University Clinical Veterinary Anatomist from Cambridge University (BSP 63).

  • Stuart Brown, MD: retired psychiatrist and founder of the National Institute for Play (BSP 60).

  • Warren S. Brown, PhD: experimental psychologist from Fuller Theological Seminary (BSP 62).

  • Guy Caldwell, PhD: molecular biologist from the University of Alabama (BSP 59).

  • Patricia Churchland, PhD: neurophilosopher from University of California at San Diego (BSP 55).

  • Chris Frith, PhD: neuropsychologist from University College London (BSP 57).

  • Allan Jones, PhD: Chief Science Officer at the Allen Institute for Brain Research (BSP 61).

  • Eve Marder, PhD: neuroscientist from Brandeis University (BSP 56).

  • Michael Merzenich, PhD pioneer in neuroplasticity (BSP 54).

  • Alva Noë, Phd: philosopher from the University of California (BSP 58)

Reminders:

Send feedback to brainsciencepodcast@gmail.com.

"Did My Neurons Make Me Do It?" with Warren Brown (BSP 62)

/

Warren Brown and Nancey Murphy

Episode 62 of the Brain Science Podcast is an interview with Warren Brown, PhD, co-author (with Nancey Murphy) of Did My Neurons Make Me Do It?: Philosophical and Neurobiological Perspectives on Moral Responsibility and Free Will.  This book was discussed in detail back in Episode 53, but this interview gave me a chance to discuss some of the book's key ideas with Dr. Brown.  We focused on why a non-reductive approach is needed in order to formulate ideas about moral responsibility that are consistent with our current neurobiological understanding of the mind.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Additional Links and References:

Allan Jones from the Allen Institute for Brain Research (BSP 61)

/

Episode 61 of the Brain Science Podcast is an interview with Allan Jones, PhD, the Chief Science Officer of the Allen Institute for Brain Research in Seattle, Washington.  The Allen Institute is a non-profit research organization founded by Paul Allen (co-founder of Microsoft) and is best known for its Mouse Brain Map, which is being used by researchers around the world.  The Institute has several other on-going projects including a project to create a map of the human cortex that shows which genes are active in each area.

In this interview we discuss both the mouse brain project and the human cortex project, with an emphasis on the importance of these projects to neuroscience research.  All the maps created by The Allen Institute are freely available on the internet.  Dr. Jones also shares his own story and the challenges and rewards of pursuing a career in the non-profit biotech world.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

SHOW NOTES

Previous Episodes mentioned in this podcast:

  • BSP 59: Interview with Guy Caldwell, PhD who studies the dopamine neurons in C. elegans.

  • BSP 60: Interview with Stuart Brown, MD about the importance of play.  This is an excellent episode for new listeners.

Announcements:

Send email feedback to Dr. Campbell at brainsciencepodcast@gmail.com.

Why Play is Essential to Brain Health with Dr. Stuart Brown (BSP 60)

/

In Episode 60 of the Brain Science Podcast, Ginger Campbell, MD, interviews Dr. Stuart Brown, author of Play: How It Shapes the Brain, Opens the Imagination, and Invigorates the Soul.  Our focus is on the importance of play for normal mental development and psychological health. We also explore the importance of play in adults.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Scientists mentioned in the podcast:

  • Anthony Pellegrini, PhD (University of Minnesota): Studies rough and tumble play.

  • Brian Sutton-Smith, PhD (Strong Museum of Play, NY): studies the storytelling aspects of play.

  • John Ratey, MD (Harvard Medical School): author of Spark: The Revolutionary New Science of Exercise and the Brain.

  • Sergio Pellis, PhD (Canadian Centre for Behavioral Neuroscience): has studied rough and tumble play in mice and rats for many years.

  • Marian C Diamond, PhD (University of California-Berkeley): pioneer in the study of effects of enrichment on the mammalian brain. Recent Video.

  • Richard Feynman, PhD (1918-1988): Nobel physicist who is also remembered for finding the cause of the Challenger disaster. (see the video)

  • Roger Guillimen, PhD (The Salk Institute): won the 1977 Nobel Prize in Medicine for "discoveries concerning the peptide hormone production of the brain."

Books about Play and Related Topics:

Useful Links:

Send email to Dr. Campbell at brainsciencepodcast@gmail.com.

Using C. elegans in Neuroscience with Guy Caldwell, PhD (BSP 59)

/

Episode 59 of the Brain Science Podcast is an interview with molecular biologist, Guy Caldwell, PhD, from the University of Alabama.  We talk about the role of the tiny worm C. elegans in neuroscience research.  Dr. Caldwell is collaborating with other leading researchers (including his wife, Kim Caldwell, PhD) in work that may lead to a cure for movement disorders like dystonia and Parkinson's Disease.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Show Notes and Links:

During this interview, Dr. Caldwell emphasized the importance of collaboration.  His work involves tagging the dopamine neurons in C. elegans with green florescent protein (GFP).  His work depends on the pioneering work of many scientists (some of whom I list below).  He also collaborate with researchers who are doing similar work in yeast, mice, and human cell cultures.

Scientists mentioned in this interview:

  • Martin Chalfie (Columbia University): Caldwell's mentor won the Nobel Prize in 2008 for his work with using Green Florescent Protein (GFP) to tag specific cells inside C. elegans.  Dr. Chalfie was interviewed on Futures in Biotech: Episode 37 and Episode 38.

  • Susan Lindquist (MIT): a leading geneticist who is using to take human alph-synuclein protein and place it into yeast to study the effects of protein clumping due to misfolding. (Futures in Biotech #1)

  • Sydney Brenner (Salk Institute): a leader in C. elegans research.

  • John Sulston (University of Manchester): pioneer in C. elegans research.

  • Robert Horvitz (MIT): well-researcher in the field of worm biology.

  • Cynthia Kenyon (University of California-San Francisco): is studying aging in C. elegans.

  • John White (University of Wisconsin): worked with John Sulston to determing the complete "wiring diagram" for C. elegans (which has only 302 neurons).

  • Jeff Becker (University of Tennessee): Caldwell's mentor in graduate school.

  • Chris Rochet (Purdue University): his study of mid brain cultures of rat neurons allows Caldwell to validate his findings in mammalian neurons.

  • Richard Myers (Boston University): human geneticist who has done important work in Parkinson patient genotyping.

  • Rudolph Jaenisch (MIT): expert at reprogramming skin cells into pleuripotent stem cells. This technique shows great promise for the treatment/cure of diseases like Parkinson's.

  • Xandra Breakefield (Harvard): discovered the torsin gene in 1997.

Three recent Nobel Prizes have been awarded to researchers working on C. elegans.

Announcements: 

  • Dr. Campbell is the guest speaker at the July 18 meeting of Skeptics in the Pub in Atlanta, Georgia.

  • Dr. Campbell was interviewed on Episode 96 of Brains Matter.

  • Transcripts are now available for all past episodes of the Brain Science Podcast.

  • Please join our new Brain Science Podcast Fan Page on Facebook.

  • Donations of $25 or more qualify you for the new monthly book give away.

Join our Discussion Forum:

Send feedback to Dr. Campbell at gincampbell at mac.com.

How our Brain Creates Our World with Chris Frith, PhD (BSP 57)

/

Episode 57 of the Brain Science Podcast is an interview with neuropsychologist, Dr. Chris Frith, author of Making up the Mind: How the Brain Creates Our Mental World.   Our brain processes information about the world outside us (via our senses) in the same way that it processes information from within our bodies and from our own mental world.  In this interview.  Dr. Frith and I explore the implications from recent discoveries about how our brain generates our mental world.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE. All episodes posted after January 1, 2013, are free. See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Useful Links:

Selected References:*

*These references are from Making up the Mind: How the Brain Creates Our Mental World by Chris Frith.

Send feedback to brainsciencepodcast@gmail.com.

Interview with Neuroscience Pioneer Eve Marder, PhD (BSP 56)

/

Episode 56 of the Brain Science Podcast is an interview with neuroscientist, Eve Marder, PhD.  Dr. Marder has spent 35 years studying the somatogastric ganglion of the lobster. In this interview we talk about how she got into neuroscience during its early days, her recent tenure as president of the Society for Neuroscience, and how some of her key discoveries have implications for studying more complex nervous systems.

How to get this episode:

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Links:

Announcements:

Does the Limbic System Exist?

/
A few days ago I received an email from a listener asking me: Does the Limbic System Exist?

The term limbic system was made popular in the late 1970's by Carl Sagan's Pulitzer Prize winning book,The Dragons of Eden; but in recent years, many neuroscientists have come to regard the term as misleading, or worse.  In this essay I will provide a brief historical overview and discuss the scientific objections to the term limbic system.

History

The highly regarded textbook, Neuroscience: Exploring the Brain (3rd edition, edited by Bear, et. al.) provides a brief overview of the history of the "limbic system concept."  It notes that the term "limbic lobe" was introduced back in 1878 by the French neurologist Paul Broca.  Broca was describing the area of the medial brain that surrounds the brain stem and corpus callosum.  By the 1930's, the evidence suggested that many of the structures in this region were involved in emotion.  One expression of this hypothesis was the so-called "Papez circuit" (named after neurologist James Papez).  In 1952, James Maclean introduced the term "limbic system," and in 1973, he proposed his famous "triune theory" of brain evolution, which was later popularized in The Dragons of Eden.

In 1998, Jaak Panksepp made extensive use of the "triune brain" model in his groundbreaking book, Affective Neuroscience: The Foundations of Human and Animal Emotions.  Panksepp emphasized that primates (including humans) share similar emotional circuitry.  This principle has inspired much valuable research into the role of emotion in our mental lives, so that we now recognize that proper functioning of our emotional circuitry is essential to our health.

Thus, the term "limbic system" actually includes two main ideas: the idea that there is a discrete part of the brain that generates mammalian emotions, and the idea that this area evolved as a separate area only in mammals.  In the triune theory of brain evolution, primates (including humans) are seen as having inherited three successive brain structures: the reptilian brain, the limbic system, and the neocortex.

Objections

In Neuroscience, the authors observe that, although the evidence certainly supports the the fact that some of the structures in this region are involved in emotion, the Papez circuit is no longer seen as an accurate description.  More importantly, they state "The critical point seems to be conceptual, concerning the definition of an emotional system.  Given the diversity of emotions we experience, there is no compelling reason to think that only one system--rather than several--is involved.  Conversely, solid evidence indicates that some structures involved in emotions are also involved in other functions..." (page 571).  Thus, they question applying the term limbic system to the emotional system, because it can not accurately be described as a discrete system of components, such as one would describe the visual system.

The second objection to the term limbic system is that it represents a model of primate brain evolution that has largely been discarded.  In Principles of Brain Evolution, Georg Striedter observed that Maclean's "triune brain" theory was "clearly derived" from the work of Ludwig Edinger (1908), who observed that that the forebrain of various vertebrates seemed to differ dramatically, while the lower brain structures appeared to be highly conserved.  The key underlying assumption of the "triune brain" theory is that major brain areas were added on as mammals evolved, but this essentially 19th century viewpoint has been supplanted by modern work in neuroanatomy.

Striedter explains how the idea that "brains evolved by the sequential addition of parts was toppled."   He concludes "By the 1990's, most comparative neuroanatomists believed that all vertebrate brains are built according to a common plan that varies only in its details."  His textbook describes the evidence in support of this "conservative revolution" in great detail. (Streitder, page 35)  Note: Striedter's book was discussed in Episode 47.

Conclusions

The term "limbic system" is clearly falling into disuse among neuroscientists, but seems destined to live on the popular imagination.  The "triune brain" popularized by Sagan and Maclean has an undeniable appeal, partly because it presents a clear and understandable model that corresponds to our intuitive sense of our place in the world.  The problem is that it represents an oversimplified, and possibly misleading picture.  Our brains are much more like those of other mammals than this model suggests.  Also, the emotional system is much more complex and deeply integrated into the other systems of the brain.

Scientists have a strong preference for precise language.  Thus, as described above, the limbic system does not exist, because there is no one clearly defined emotional system in the human brain.  Many neuroscientists (especially those involved in comparative neuroanatomy) also avoid the term because of its association with an outmoded view of vertebrate brain evolution.
 

References

Michael Merzenich Talks About Neuroplasticity (BSP 54)

/

Brain Science Podcast #54 is an interview with Dr. Michael Merzenich, one of the pioneers of neuroplasticity.  We talk about how the success of the cochlear implant revealed unexpected plasticity in adult brains and about how brain plasticity can be tapped to improve a wide variety of problems including dyslexia, autism, damage from disease and injury.  Healthy people of all ages can also tap the resource of brain plasticity to help maintain and improve their mental functions.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Links and References

Previous Episodes on Brain Plasticity

Send email feedback to Ginger Campbell, MD at brainsciencepodcast@gmail.com

Review: "Did My Neurons Make Me Do It?" (BSP 53)

/

Episode 53 of the Brain Science Podcast is a discussion of Did My Neurons Make Me Do It?: Philosophical and Neurobiological Perspectives on Moral Responsibility and Free Will, by Nancey Murphy and Warren S. Brown.  This book challenges the widespread fear that neuroscience is revealing an explanation of the human mind that concludes that moral responsibility and free will are illusions created by our brains.

Instead, the authors argue that the problem is the assumption that a physicalistic/materialistic model of the mind must also be reductionist (a viewpoint that all causes are bottom-up).  In this podcast I discuss their arguments against causal reductionism and for a dynamic systems model.  We also discuss why we need to avoid brain-body dualism and recognize that our mind is more than just what our brain does. The key to preserving our intuitive sense of our selves as free agents capable of reason, moral responsibility, and free will is that the dynamic systems approach allows top-down causation, without resorting to any supernatural causes or breaking any of the know laws of the physical universe.  This is a complex topic, but I present a concise overview of the book's key ideas.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Additional Show Notes

References:

  • Books and Ideas #12 ("The Myth of Free Will")

  • Alice Juarrero, Dynamics in Action: Intentional Behavior as a Complex System.

  • Terence Deacon, The Symbolic Species: The Co-Evolution of Language and the Brain.

  • Terrence Deacon, "Three Levels of Emergent PHenomena," in Nancy Murphy and William R. Stoeger (eds.) Evolution, and Emergence: Systems, Organisms, Persons (OUP 2007) ch 4.

  • Alwyn Scott, "The Development of Nonlinear Science", Revista del Nuovo Cimento, 27/10-11 (2004) 1-115.

  • Roger W. Sperry, "Psychology's Mentalist Paradigm and the Religion/Science Tension," American Psychologist, 43/8 (1988), 607-13.

  • Donald T. Campbell, "'Downward Causation' in Hierarchically Organized Biological Systems." in F. J. Ayala and T. Dobzhansky (eds.) Studies in the Philosophy of Biology 179-186.

  • Steven Johnson, Emergence: The Connected Lives of Ants, Brains, Cities, and Software

  • Robert Van Gulick, "Who's in Charge Here? And Whose Doing All the Work?"In Heil and Mele (eds.) Mental Causation, 233-56.

  • George Lakoff and Mark Johnson, Philosophy in the Flesh: The Embodied Mind and Its Challenge to Western Thought.

  • Ludwig Wiggenstein, Philosophical Investigations.

Other scientists mentioned in the episode:

  • Antonio Damasio: Descartes' Error: Emotion, Reason, and the Human Brain.

  • Arthur Glenberg: interviewed in Episode 36.

  • Rolf Pfeifer: interviewed in Episode 25.

  • Leslie Brothers, Friday's Footprint: How Society Shapes the Human Mind.

  • Raymond Gibbs, Embodiment and Cognitive Science.

  • Andy Clark, Being There: Putting Brain, Body, and World Together Again.

  • Gerald M.Edelmanand Guilo Tononi, A Universe of Consciousness: How Matter Becomes Imagination.

Donations and Subscriptions are appreciated

Send email feedback to Ginger Campbell, MD at brainsciencepodcast@gmail.com

Review of Year 2 of the Brain Science Podcast (BSP 52)

/

Brain Science Podcast #52 is our Second Annual Review Episode.  We review some of the highlights from 2008.  I also discuss the various other on-line resources that I have created for listeners.  Then we look ahead to what I have planned for 2009. This episode is aimed at all listeners, including those who are new to the show.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Highlights from 2008:

Early in the year (#30) I discussed language evolution.  My criticism of Noam Chomsky's claim that human language results from a Universal Grammar Module generated quite a bit of discussion.  My main purpose was to emphasize that current neuroscience does not support this hypothesis.  I discussed Chomsky's work in follow-up interviews with Dr. Michael Arbib (BSP 39) and linguist Alice Gaby (BSP 41).

It is my impression that, at least to some extent, this debate comes back to the age-old "nature versus nurture" controversy, which I discussed more explicitly way back in Episode 4.  The evidence seems to be mounting that human intelligence is a product of  both processes.

There is no doubt that the capacity for language is inherited, but brain plasticity appears to be equally important.  One piece of evidence for this is that the changes in the brain that occur when people learn to read are different between languages like English and German and those like Chinese and Japanese. (Episode 24 and Episode 29)

We had 17 guests on the Brain Science Podcast in 2008, so I can't mention them all here.

  • John Ratey, MD: In Episode 33 we talked about exercise and the brain, while in Episode 45 we talked about ADD.

  • Robert Burton, MD:  In Episode 43 talked about the implications of the discovery that our sense of knowing (feeling certain) is generated by parts of the brain that are outside our conscious control!

  • John Medina, PhD: In Episode 37 we considered the practical implications of neuroscience, such as the importance of getting enough sleep and why true multi-tasking is actually impossible.

  • Dr. Brenda Milner: In Episode 49 this pioneering neuroscientist shared highlights from her long career.

Another highlight was our first live podcast, which was recorded at Dragon*Con in Atlanta, Georgia on August 31.

In the fall I returned to the subject of evolution with a three part series on the evolution of the brain.

  • Episode 47, Episode 48, and Episode 51.

  • Episode 51 is an outstanding interview with Dr. Seth Grant in which we discuss the surprising discovery that synapse complexity seems to have evolved BEFORE larger more complex brains.

Online Resources for Listeners:

  • I encouraged listeners to frequent this website and to subscribe to the RSS feed so as to receive information between posts.

  • I encouraged listeners to explored the sidebars and tabs on the website for links to other sites of interest.

  • I reminded listeners that this website includes a complete listing of previous episodes as well as a list of all the guests that have been on the show.

  • It is now possible to support the Brain Science Podcast  via both PayPal and by direct mail.

  • I encouraged listeners to participate in our Discussion Forum and to post pictures to our Flickr Group.

  • I invited listeners to contribute content to the Brain Science Podcast Room on FriendFeed and the new Neuroscience News Network on SocialMedian.

  • I reminded listeners that my personal blog is now at http://gingercampbellmd.com.  This site includes abridged show notes for the Brain Science Podcast as well as the complete show notes for Books and Ideas.

  • Listeners are encouraged to continue to post reviews on iTunes™, Podcast Pickle, Podcast Alley, Digg, and similar sites. All blog posts and tweets are greatly appreciated.

Send email feedback to Ginger Campbell, MD at brainsciencepodcast@gmail.com

Surprising Discoveries about Synapse Evolution with Seth Grant (BSP 51)

/

Episode 51 of the Brain Science Podcast is an interview with Dr. Seth Grant from Cambridge University, UK.  Dr. Grant's work focuses on the proteins that make up the receptors within synapses.  (Synapses are the key structures by which neurons send and receive signals.)  By comparing the proteins that are present in the synapses in different species, Dr. Grant has come to some surprising conclusions about the evolution of the synapse and the evolution of the brain.

In this interview, Dr. Grant explains how his research team has uncovered the identity ofsynapse proteins in a variety of species including yeast, fruit flies, and mice.  Our discussion is centered on the paper he published in Nature Neuroscience in June 2008.  Dr. Grant's team has made several surprising discoveries.  First, he has discovered that some proteins associated with neuron signaling are actually found in primitive unicellular organisms like yeast. He has also discovered that the protein structure of the synapse becomes more complex as one moves from invertebrates like fruit flies to vertebrates like mice, but that most of the complexity seems to have arisen early on in vertebrates.

According to Dr. Grant:

The origins of the brain appear to be in a protosynapse, or ancient set of proteins found in unicellular animals; and when unicellular animals evolved into metazoans, or multicellular animals, their protosynaptic architecture was co-opted and embelished by the addition of new proteins onto that ancient protosynaptic set; and that set of new molecules was inserted into the junctions of the first neurons, or the synapse between the first neurons in simple invertebrate animals.  When invertebrates evolved into vertebrates, around a billion years ago, there was a further addition, or enhancement of the number of these synaptic molecules, and that has been conserved throughout vertebrate evolution, where they have much larger numbers of synaptic molecules.  The large complex synapses evolved before large anatomically complex brains.

The discovery that there are significant differences between the synapses in vertebrates and non-vertebrates is significant, because it has long been assumed that synapses were essentially identical between species, and that brain and behavioral complexity was based on having more neurons and bigger brains.  Instead, Dr. Grant proposes an alternative hypothesis:

The first part of the brain to ever evolve was the protosynapse. In other words, synapses came first.

When this big synapse evolved, what the vertebrate brain then did, as it grew bigger and evolved afterwards; it exploited the new proteins that had evolved into making new types of neurons in new types of regions of the brain. In other words, we would like to put forward the view that the synapse evolution has allowed brain specialization, regionalization, to occur.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Addition Show Notes and Links

References:

Blog posts and other links:

Learn more about Dr. Grant's work:

Send email feedback to Ginger Campbell, MD at brainsciencepodcast@gmail.com.