Interview with Jeff Hawkins "On Intelligence" (BSP 38)

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Episode 38 of the Brain Science Podcast is an interview with Jeff Hawkins, author of On Intelligence.  Hawkins is well-known for founding Palm Computing and Handspring.  He invented the Grafitti handwriting recognition system and helped develop the Palm Trio SmartPhone.  Since he published his bestseller On Intelligence, he has devoted his work to his passion for neuroscience.  His current company, Numenta, is developing software that models the hierarchical structure of the neocortex.  In this interview we talk about the ideas in Hawkins book and how he is applying them to develop a computer model of cortical function.  This is a follow-up to Episode 2, which first aired in December of 2006.

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Links and References:

Vernon Montcastle: pioneer who proposed that all parts of the brain's cortex work the same way.

  • Vernon Mountcastle (1978), "An Organizing Principle for Cerebral Function: The Unit Model and the Distributed System", The Mindful Brain (Gerald M. Edelman and Vernon B. Mountcastle, eds.) Cambridge, MA: MIT Press (Please let me know if you find this paper on-line!)

Redwood Institute for Theoretical Neuroscience (UC-Berkeley) founded by Jeff Hawkins.

Numenta: company website includes extensive educational information about hierarchical temporal memory system (HTM).  The company's focus is practical implementation of HTM Theory.

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"Brain Rules" with John Medina (BSP 37)

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John Medina, PhD

Episode 37 of the Brain Science Podcast is an interview with Dr. John Medina, author of Brain Rules: 12 Principles for Surviving and Thriving at Work, Home, and School.  We talk about how exercise, sleep, and stress effect our brains, with an emphasis on practical advice for healthier brain function.  We also look at how research on memory, vision, and the brain's attention system suggests how we can improve our ability to learn and our ability to share ideas with others.

Dr. Medina's focus is on considering real world examples of how our schools and work environments could be reformed to utilize the growing knowledge of neuroscience.  But he also stresses the importance of compiling sufficient experimental data before embarking on new programs.

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Links and References:

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Embodied Cognition with Art Glenberg (BSP 36)

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Episode 36 of the Brain Science Podcast is an interview with Arthur Glenberg, PhD, about embodied cognition.  Dr. Glenberg recently moved to Arizona State University, after over 30 years at the University of Wisconsin's Laboratory of Embodied Cognition.  His research focuses on the relationship between embodiment and language.  In this interview, we explore the experimental evidence for a theory of language that embraces the concept that our language abilities are actually rooted in our perceptual and motor abilities.  Dr. Glenberg also explains how his work has practical implications in helping children learn how to read.

Since Dr. Glenberg has had a long career as a working research scientist, this interview also provided an opportunity to explore how scientific hypotheses are formed and how experiments are designed to test these hypothesis.  I think this interview will give you a fascinating look into the real world of cognitive psychology.

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Links and References:

Arthur Glenberg, PhD

Other scientists mentioned in the Episode:

  • George Lakoff: pioneering linguist.

  • James Gibson: known for his ideas about affordances.William Epstein-emeritus professor at the University of Wisconsin.

  • Joseph Campos: University of California (Berkelely).

  • Amy Needham and Amanda Woodard-experiments with velcro mits and infant cognition.

  • David A Havas: graduate student and co-author with Dr. Glenberg.

  • Mike Kashak: Florida State University.

  • Mike Rinck: German co-author-see paper under Glenberg.

  • Vittorio Gallese, Dept of Neuroscience, University of Parma, Italy (where mirror neurons were discovered): extensive experimental with motor neurons in monkeys.

  • Fritz Stack (Germany): experiments showing that facial experiments affect mood and cognition.

References:

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Rachel Herz Talks About Smell (BSP 34)

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Episode 34 of the Brain Science Podcast is an interview with Rachel Herz, author of The Scent of Desire: Discovering Our Enigmatic Sense of Smell (2007).  Dr. Herz teaches at Brown University, and she is a leading authority on the psychology of smell.  We talk about the how smell works, its role in emotion and memory, why it is so vulnerable, and why smell is much more important than most of us realize.  We also consider some of the questions that remain unanswered.

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Links and References:

Rachel Herz:

The 2004 Nobel Prize for Medicine and Physiology was awarded to Richard Axel and Linda B. Buck for their discoveries of "odorant receptors and the organization of the olfactory system."

BuckL, Axel R.: "A novel multigene family may encode odorant receptors: a molecular basis for odor recognition."

Cell. 1991 Apr 5;65(1):175-87.

"The (Shocked) Nose Knows" by Gisela Telis Science NOW Daily News 27 March 2008.

The Scent of Desire: Discovering Our Enigmatic Sense of Smell (2007), by Rachel Herz

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Exercise and the Brain (BSP 33)

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John J. Ratey, M.D.

Episode 33 of the Brain Science Podcast is an interview with Harvard physician, Dr. John Ratey, about his new book, Spark: The Revolutionary New Science of Exercise and the Brain.

We explore the exciting evidence about how exercise helps the brain.  It stimulates the release of a number of different neurotransmitters and neuropeptides, but probably more importantly, it helps keeps these compounds balanced.  We consider why exercise is so important in dealing with stress, in treating a wide range of mental illnesses including depression, anxiety, and attention deficit disorder.  There is also evidence that exercise improves our ability to learn and our ability to avoid the loss of mental agility associated with aging.

We explore the exciting evidence about how exercise helps the brain.  It stimulates the release of a number of different neurotransmitters and neuropeptides, but probably more importantly, it helps keeps these compounds balanced.  We consider why exercise is so important in dealing with stress, in treating a wide range of mental illnesses including depression, anxiety, and attention deficit disorder.  There is also evidence that exercise improves our ability to learn and our ability to avoid the loss of mental agility associated with aging.

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This episode contains information that everyone can use.  I hope you will share it with your friends and family.

Links and References:

Brain Science Podcast #31: Brain Rhythms with György Buzsáki

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György Buzsáki, author of Rhythms of the Brain  (OUP 2006), is a professor of neuroscience at Rutgers University.  His book is a comprehensive review of the current state of research in the field of brain oscillations.  It includes the role of these oscillations in sleep and memory.  In Episode 31 of the Brain Science Podcast, Dr. Buzáki explains why the rhythms of the brain are important and reflects on why this field has been neglected by some neuroscientists.  I think he makes a convincing case for the position that these rhythms are an essential component of brain function.

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Scientists and References:

  • Stephen Strogatz: known for his discovery of "small world" architecture.: His 2003 bestseller Sync: The emerging science of spontaneous order is aimed at a general audience

  • Nancy Kopell: mathematician: Buzsaki recommends her review of the analytical approaches to neuronal oscillators: We got Rhythm: Dynamical Systems of the Nervous System. N Am Math Soc 47: 6-16 (2000).

  • Zoltán Néda (Bebes-Bolyai University Romania): the spontaneous synchronization of hand clapping

  • Hermann Haken: German laser physicist who studies bidirectional causation.

  • The Science of Structure: Synergetics (1984).

  • John O'Keefe (University College,  London): along with Lynn Nadel he discovered how the hippocampus forms a cognitive map of the world. He has shown how the timing of oscillations in the hippocampus are important.

  • "Independent rate and temporal coding in hippocampal pyramidal cells," by John Huxter, Neil Burgess, and John O'Keefe. Nature 425, 828-832 (23 October 2003).

  • David McCormick (Yale University): showed that neurons from the thalamus of a ferret can oscillate spontaneously.  He has also studied the oscillations of place cells in the hippocampus.

  • David Hubel and Thorston Wiesel: along with Vernon Montcastle, they pioneered the use of single neuron recordings in the neocortex of casts and monkeys.

  • Montcastle, VB (1997), "The Columnar Organization of the Neocortex." Brain 102:01-722.

  • Claude Shannon: founder of Information Theory.

  • Jan Born (University of Lübeck, Germany): experiments with how sleep improves both memory and problem solving.

Topics and questions:

  • Basics of oscillations and synchrony.

  • What functions are accomplished by brain rhythms?

  • The role of hippocampal ripples in memory.

  • What happens to our brain rhythms while we sleep.

  • The importance of synchrony in saving energy in the brain.

This episode will appeal to listeners with a background in math or engineering, but Dr. Buzsáki provides numerous everyday examples that make the material accessible to everyone.

Natasha Mitchell Interviews Jonah Lehrer about "Proust was a Neuroscientist"

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The February 9th episode of All in the Mind  is an excellent interview of author Jonah Lehrer about his book Proust Was a Neuroscientist.  In the interview, Lehrer reflects on the danger of viewing science as the sole source of discovery, but he also talks a little about several of the people explored in his book.  His basic premise is that artists from various fields often intuitively grasped truths that are now being revealed by neuroscience.  One example is the insights that Proust had about memory.

Proust was a Neuroscientist is a valuable contribution to the current exploration of the relevance of neuroscience to everyday life.  It can be easily read in a few sittings or savored one artist at a time.

Natasha Mitchell is an excellent interviewer because she always asks interesting and probing questions.  (I think of her as the Australian Terry Gross.).  All in the Mind is an excellent compliment to the Brain Science Podcast.

Mitchell has recently begun an All in the Mind blog and there is a new All in the Mind group on Facebook.

The Evolution of Language (BSP 30)

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Episode 30 of the Brain Science Podcast is a discussion of The First Word: The Search for the Origins of Language, by Christine Kenneally.  We focus mostly on the first part of the book, which tells the story of how the study of language evolution has grown from almost a banned subject to a new field of inquiry called evolutionary linguistics.  We also reflect on how recent findings in neuroscience like the importance of plasticity are influencing the field.

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Scientists discussed in the Episode:

*References:

*Additional references can be found in Kenneally's book and at the websites of the scientists listed above.  Also, be sure to check out Kenneally's blog for follow-up information.

Reading and the Brain with Dr. Maryanne Wolf (BSP 29)

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Dr. Maryanne Wolf, Director of The Center for Reading and Language Research at Tufts University

Episode 29 of the Brain Science Podcast is an interview with cognitive neuroscientist, Dr. Maryanne Wolf, author of Proust and the Squid: The Story and Science of the Reading Brain.  I discussed her book in Episode 24, so this interview was an opportunity to ask her some follow-up questions, and to focus more on how children learn to read.  Dr. Wolf shares her ten years of experience helping children learn to read and developing programs to help children with problems like dyslexia.  She shares some practical advice for parents as well as her concerns about how reliance on the internet could influence reading skills.

I enjoyed the conversation and, while I especially want to share this episode with parents, I think Dr. Wolf gives everyone some interesting ideas to consider. 

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Links:

Maryanne Wolf

Edward Taub's Revolutionary Approach to Stroke Rehabilitation (BSP 28)

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Edward Taub, PhD, pioneer of Constraint-Induced Movement Therapy

Episode 28 of the Brain Science Podcast is an interview with Dr. Edward Taub, who for the last 20+ years has been pioneering the use of Constraint-Induced Movement Therapy in the rehabilitation of stroke and other neurological disabilities.  I have talked about his work in previous episodes (including Episode 10 and Episode 26) as an important example of the practical implications of brain plasticity. 

In this interview,  Dr. Taub shares his personal experiences in the front lines of clinical research, including both its rewards and frustrations.  He also explains the basics of how constraint-induced therapy (CI Therapy) works and how his work is being expanded to help patients with a wide variety of problems including cerebral palsy, head trauma, multiple sclerosis, and focal hand dystonia.

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Links and References:

Dr. Taub recommends that interested listeners do their own Google search under "constraint-induced movement therapy" or CI Therapy, but I have included a few links below:

About Dr. Taub:

References:

  • Effect of Constraint-Induced Movement Therapy on Upper Extremity Function 3 to 9 Months After Stroke: The EXCITE Randomized Clinical Trial: Steven L. Wolf; Carolee J. Winstein; J. Philip Miller; EdwardTaub; Gitendra Uswatte; David Morris; Carol Giuliani; Kathye E. Light; Deborah Nichols-Larsen; JAMA, November 1, 2006;   296:   2095 - 2104.  (Free download)

  • Accompanying editorial: Stroke Recovery-Moving in an EXCITE-ing Direction: Andreas R. Luft, MD;  Daniel F. Hanley, MD; JAMA. 2006;296:2141-2143.  (Available for purchase)

Neuroplasticity with Dr. Norman Doidge (BSP 26)

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Episode 26 of the Brain Science Podcast is an interview with Dr. Norman Doidge, MD, author of The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science (2007).  Dr. Doidge and I agree that neuroplasticity is the most important discovery about the brain that has been made in several hundred years.  In his interview, Dr. Doidge talks about some of the obstacles that delayed this discovery including what he calls the "plastic paradox," which is the fact that plasticity itself can contribute to the development of rigid behaviors, including addictions and bad habits.

The Brain That Changes Itself includes the work of the key scientists of neuroplasticity.  In my conversation with Dr. Doidge, we talked about the work of Paul Bach-y-Rita, Edward Taub, and VS Ramachandran.  Dr. Doidge also shared how his own work is being affected, and why he thinks neuroplasticity has the potential to lead to more important discoveries.

I will be talking to Dr. Taub in Episode 28.  If you are new to the Brain Science Podcast, you may want to go back and listen to Episode 10, which is where I first introduced neuroplasticity in my discussion of Train Your Mind, Change Your Brain: How a New Science Reveals Our Extraordinary Potential to Transform Ourselves, by Sharon Begley.

You can learn more about Dr. Doidge's work at his website: http://normandoidge.com

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Embodied Intelligence with Rolf Pfeifer (BSP 25)

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How the Body Shapes the Way We Think, by Rolf Pfeifer and Josh Bongard

Brain Science Podcast  Episode 25 is an interview of author Rolf Pfeifer, director of the Artificial Intelligence Laboratory at the University of Zurich.  The focus of our conversation was the importance of embodiment.  Brains (and intelligence) cannot be understood separate from their interaction with the body and the physical world.  Pfeifer explains how this realization has led the field of artificial intelligence away from a pure computational approach to one he calls embodied artificial intelligence.  His interview is spiced with numerous examples that demonstrate why this approach is relevant to those of us who are interested in the human brain. 

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Episode Highlights:

  • A brief overview of artificial intelligence.

  • Introduction to biorobotics.

  • Why artificial intelligence and biorobotics are relevant to understand the brain.

  • The meaning of complexity and emergence.

  • Why the close coupling of the sensory and motor systems is essential to intelligence.

  • Applying design principles to understanding intelligence.

  • Numerous examples make these potentially intimidating topics accessible to all listeners.

  • I also introduced a new way for listeners to support the Brain Science Podcast 

Related episodes of the Brain Science Podcast:

Scientists mentioned in the podcast:

Books by Rodney Brooks:

Where to learn more about Pfeifer's work:

Sandra Blakeslee (BSP 23)

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This episode is an interview with Sandra Blakeslee, co-author (with her son Matthew) of The Body Has a Mind of Its Own: How Body Maps Help You Do (almost) Everything Better, which we discussed in Episode 21.

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Show Notes

I asked Blakeslee to tell me a little bit of her background as a science writer.  She wrote for the New York Times for many years and was the co-author of both Jeff Hawkins groundbreaking book, On Intelligence, and VS Ramachandran's modern classic Phantoms in the Brain (1998), which was one of the first books to explore neuroplasticity.

In this interview, we explored the relationship between body maps and neuroplasticity, as well as questions from listeners about out of body experiences and other oddities once considered "paranormal."  We talked about how body maps are relevant to understanding why some methods of alternative healing appear to be effective.

I asked her to tell me which scientist she met made the biggest impression.  Here are a few of those she mentioned:

Blakeslee told me about some of the pioneering work that Merzenich is doing to apply his discoveries to help people, both those with disabilities and those who just want to combat aging.  You can learn more about his work at http://www.positscience.com/.

If you would like to contact Sandra Blakeslee to give her feedback or ask her questions, she has a contact form on her books website at http://www.thebodyhasamindofitsown.com/.  She is going to let me know when she gets the references posted on the site.

Consciousness with Christof Koch (BSP 22)

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Brain Science Podcast #22 is an interview with Dr. Christof Koch of Cal Tech, one of the pioneers in the neurobiological study of consciousness.  About two decades ago, when Koch and Francis Crick began looking for what they called the neural correlates of consciousness (NCC), such a quest was considered controversial; but now the field is increasing in popularity.  In our interview, we talked a little about his book,The Quest for Consciousness, as well as his on-going research and his thoughts about what the future might bring.

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Here is a list of some of the topics we discussed:

  • Why Francis Crick was an outstanding mentor and colleague.

  • A Working definition of consciousness.

  • How consciousness relates to awareness.

  • What are neural correlates of consciousness.

  • Why vision is the focus of Koch's research.

  • The search for the "footprints" of consciousness.

  • The role of functional imaging and the use of monkeys.

  • Neurons-"the atoms of perception".

  • Why we need a theory of consciousness.

  • The role of the frontal lobes in consciousness.

  • Is consciousness an emergent property?

  • What about zombies?

  • Why do we need consciousness?

  • Will artificial intelligence become conscious?

  • The hard problem:  how does the brain generate subjective experience  (qualia).

Links:

Update on 2012-05-03 15:42 by Ginger Campbell, MD

Christof Koch returned to the Brain Science Podcast in Episode 84.

"The Female Brain" with Dr. Louann Brizendine (BSP 20)

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Episode 20 of the Brain Science Podcast is an interview with Dr. Louann Brizendine of the Women's Mood and Hormone Clinic at the University of California at San Francisco.   Her book, The Female Brain, was just released in paperback, and it is on the New York Times Bestseller list.

We explore how hormones and neurotransmitters effect our brains, and how these effects are different in men and women.  This episode has interesting stuff for listeners of both sexes.

If you would like to learn more, visit Dr. Brizendine's website at http://louannbrizendine.com.

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Interview with Elkhonon Goldberg, PhD (BSP 18)

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Episode 18 of the Brain Science Podcast is an interview with Dr. Elkhonon Goldberg, PhD.

Show Notes:

  • I apologize for the uneven sound quality of this episode.  If any one out there has any suggestions, please drop me an email.

  • Dr. Goldberg shared a little bit about the breadth of his work as a neuropsychologist.

  • We talked about his rather unique perspective on the difference between the right and left brain hemispheres.  He explained why he feels that as we get older we move from reliance on the right hemisphere, which he feels is the novelty hemisphere, to a reliance on the left hemisphere, where our lifetime store of patterns enables us to use pattern recognition as a short cut in problem solving.

  • We talked about the importance of constant mental challenge, and Dr. Goldberg gives his advice about how we can keep our brains healthy through out our lives.

Links:

The following are two companies that Dr. Goldberg is working with to provide information to the public and also tools for cognitive enhancement:

  • SharpBrains:  This is a clearing house for information, and they evaluate many of the products currently being offered.

  • HeadStrong Cognitive Fitness:  This Australian company offers a net-based program for cognitive enhancement based on Dr. Goldberg's research.  I am hoping to test their products in the near future.

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"Why Choose this Book?" with Read Montague (BSP 15)

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Show Notes

Episode #15 of the Brain Science Podcast is an interview with Dr. Read Montague of the Baylor School of Medicine.  We discuss his recent book, Why Choose this Book? How we Make Decisions (2006).

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Here are some of the questions we discussed:

  • What is computational neuroscience?

  • What is the computational theory of the mind (CTOM)?

  • How isthe objection that the CTOM doesn't account for meaning answered ?

  • What about choice and responsibility?

  • Is there room for free will in this model?

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The Sci Phi Show: Interview of David Chalmers about Consciousness

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On the Brain Science Podcast #5 I talked about Consciousness and mentioned that David Chalmers is a proponent of a modern version of dualism and also quite concerned with what he calls the "hard problem;" which is explaining the subjective nature of consciousness, which he has called qualia.  If you would like to hear him explain some of these ideas himself, I suggest you listen to Jason Rennie's interview of David Chalmers on The Sci Phi Show  Outcast #36.

One thing that surprised me in the interview was that he actually defined consciousness as subjective awareness.

I  don't share Chalmers' views on these issues, but I think is a good interview, because Jason always lets his guest speak for themselves.

Latest Episode of Books and Ideas Posted in Brain Science Podcast Feed

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This week's episode of Books and Ideas is a discussion of the book, Challenging Nature: The Clash of Science and Spirituality at the New Frontiers of Life , with author Lee M. Silver of Princeton University.  I have inserted it into the Brain Science Podcast feed so that listeners can sample my second podcast. If you are already subscribed to both podcasts this will be a duplicate, which you can delete.