"The Autistic Brain" by Temple Grandin (BSP 98)

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 The Autistic Brain: Thinking Across the Spectrum  by Temple Grandin (with Richard Panek), is a tremendous gift, not just to patients and their families, but also to teachers, mentors, friends, and everyone who is interested in understanding how our brains make us who we are.

I think that this is a book everyone should read because as we come to appreciate the fact that the strengths and challenges of autism occur across a broad spectrum, we may also realize that some of these issues actually affect people who aren't considered autistic.  It is not the label that matters.  What does matter is recognizing that each of us has his or her own strengths and weaknesses, but thanks to brain plasticity, we all have the potential to nurture our strengths and, when necessary, accommodate our weaknesses.

 

How to get this episode:

  • Buy Transcript for $1.

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • New episodes of the Brain Science Podcast are always FREE. All episodes posted after January 1, 2013, are free. See the individual show notes for links the audio files.

References and Related Episodes:

Announcements: 

  • I am still trying to schedule an interview with Dr. Temple Grandin, but there is a possibility that the next episode of the Brain Science Podcast will not come out until August 2013.

  • The Deadline for listener submissions to Episode 100 is August 1, 2013.

  • Several products are not available directly on this website including the PDF version of Are You Sure? The Unconscious Origins of Certainty by Ginger Campbell, MD and a zip file contain BSP 1-10. Click here to learn more.

  • Be sure to sign up for the Brain Science Podcast Newsletter so that you can receive show notes automatically and NEVER miss a new episode. (But there was a glitch last month, so if you did not get the show notes for BSP 97, please click here.

Neuroanthropolgy: What Is It and WHY Should You Care? (BSP 97)

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You may be tired of seeing the prefix "neuro" used to describe every new fad, but The Encultured Brain: An Introduction to Neuroanthropology [2012] edited by Daniel H. Lende and Greg Downey makes an impassioned argument for why neuroscience and anthropology should be working together to unravel the ongoing mystery of how our brains make us who we are.  The latest Brain Science Podcast  (BSP 97) is a thought-provoking conversation with Downey and Lende.  After explaining that anthropology can offer neuroscience field data about "brains in the wild," we explore two case studies that demonstrate the promise of this new partnership.

How to get this episode:

Subscribe to the Brain Science Podcast or listen on the BSP Mobile app.

References and Links:

Announcements:

  • he Brain Science Podcast is nearing episode 100! I want to include listener comments. Send your emails and mp3 files to brainsciencepodcast@gmail.com or click here to learn more.

  • The Brain Science Podcast Newsletter has moved to Mailchimp. Click here for the new sign-up form.

  • Please nominate the Brain Science Podcast as one of the best science podcasts on the web at http://www.thesciencestudio.org.

  • Keep an eye out for the latest BSP News!

Robert Burton's "Skeptic's Guide to the Mind" (BSP 96)

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​Robert Burton, MD

​Robert Burton, MD

In On Being Certain: Believing You Are Right Even When You're Not, Robert Burton showed that the feeling of certainty, which is something we all experience, has its origin in brain processes that are both unconscious and inaccessible to consciousness . Now in his new book, A Skeptic's Guide to the Mind: What Neuroscience Can and Cannot Tell Us About Ourselves, he extends these ideas to other mental sensations such as our feeling of agency and our sense of causation.  The idea that much of what our brain does is not accessible to our conscious awareness is NOT new, but Dr. Burton considers the implications for our understanding of the MIND.

When we talked recently (BSP 96), Dr. Burton explained that his new book has two main parts.  In the early chapters, he extends the principles he developed in On Being Certain to other mental sensations. We tend to take things like our feeling of certainty, agency, and causation for granted, but he points out that these are generated in parts of the brain that we can neither access or control.  What makes A Skeptic's Guide to the Mind stand out is that Burton then explores the implications of this reality. He argues that while we can become ever more knowledgeable about how our brain works, the MIND, which is something that we each experience subjectively, is much more elusive.

The fact that we are trying to study the MIND with the MIND has inherent limitations and I think that Dr. Burton is right when he says our response should be HUMILITY.

How to get this episode:

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Related Episodes:

  • BSP 42: A discussion of On Being Certain

  • BSP 43: Interview with Robert Burton about On Being Certain

  • BSP 67: Interview with Thomas Metzinger, author of The Ego Tunnel

  • BSP 85: Interview with Sebastian Seung, author of Connectome.

Send me feedback at brainsciencepodcast@gmail.com.

Understanding Pain (BSP 95)

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In Understanding Pain: Exploring the Perception of Pain,  Dr. Fernando Cervero does a wonderful job of condensing his 40+ years of research and immersion in the field of pain research into a concise but readable account.  It's a great introduction, and it's bound to inspire a new generation of physicians and researchers.

I interviewed Dr. Cervero in BSP 93, and this month's podcast (BSP 95) is the promised second part of our discussion of pain.  I focus on some of the topics that Dr. Cervero and I did not have time to discuss, including a look at how the mechanisms of acute pain differ significantly from those of chronic pain.  The growing appreciation of these differences offers hope to the millions of people around the world who suffer from chronic pain, but the ongoing efforts of researchers like Dr. Cervero also offer hope of improved pain relief for everyone.

Unfortunately, for those of you who love audiobooks, Understanding Pain, is not available in audio; but it is a relatively short book (under 200 pages) that I recommend to everyone.  

How to get this episode:

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References and Links:

Announcements:

Pain is a Complex Emotional and Sensory Experience (BSP 93)

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Dr. Fernando Cervero of McGill University has been studying pain since the beginning of his career back in the 1960s.  These decades have seen tremendous advances in our neuroscientific understanding of what causes different types of pain, as well as changing attitudes.  Pain was once regarded as something that most people had to endure, but now most of us demand adequate pain relief, sometimes even to the point of not tolerating minor pain.  Dr. Cevero's new book, Understanding Pain, provides an accessible account of both the history of pain research and a thoughtful consideration of the challenges facing the field.

The latest episode of the Brain Science Podcast  (BSP 93) is an interview with Dr. Cervero.  This is Part 1 of a planned two-part series.

How to get this episode:

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Meet Dr. Campbell in Person:

  • Downtown Atlanta, Georgia February 19-21, 2013.

  • South by SouthWest: March 7-10, 2013 (Austin, TX, USA).

  • Johannesburg, South Africa April 8,9 2013.

I would love to some listener meetups, so please drop me an email at gincampbell at mac dot com, if you will be at any of these places on the right days.

Other Announcements:

Reminders:

  • Don't forget to get your copy of my eBook, Are You Sure? The Unconscious Origins of Certainty, from Amazon.com. If you don't have the Kindle app, just send me your Amazon receipt and I will send you the PDF.

  • The Brain Science Podcast is supported by listener donations. It also relies on your word of mouth, so don't forget to share it with others.

  • Join the Brain Science Podcast Fan Page on Facebook, Google+, and share your thoughts in our Discussion Forum on Goodreads. Of course, you can also send me email at brainsciencepodcast@gmail.com.

  • To get show notes automatically and never miss an episode of the Brain Science Podcast, sign up for the BSP Newsletter.

Neuroscience Highlights for 2012 (BSP 92)

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The Brain Science Podcast recently passed 4 million downloads and it remains entrenched at or near the top of the iTunes rankings for Science and Medicine. So now it's time for our 6th Annual Review Episode. The purpose of this year-ending podcast is to review some of the year's highlights and key ideas. As I reviewed the transcripts of this year's episodes, I was struck by the fact that although each episode stands alone, they also inform one another. One unifying theme was the importance of taking an evolutionary approach to understanding how the human brain generates complex features like mind and consciousness.

How to get this episode:

  • FREE: audio mp3 (click to stream, right click to download)

  • Buy Transcript for $1.

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files. 

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Interviews have become an outstanding feature of the Brain Science Podcast. This year I interviewed 10 scientist, including five who have appeared in past podcasts.

Scientists Interviewed in 2012:

#Indicates returning guest. See Guest List for previous episode.

*See the Bibliography page for books featured on the Brain Science Podcast.

In addition to discussing the books by these guests, I also reviewed Who's in Charge?: Free Will and the Science of the Brain, by Michael S. Gazzaniga, and Self Comes to Mind: Constructing the Conscious Brain, by Antonio Damasio.

Related Episodes: 

  • BSP 32: Brief Introduction to brain anatomy.

  • BSP 47: Basics of brain evolution.

  • BSP 57: Chris Frith, author of Making up the Mind: How the Brain Creates Our Mental World.

  • BSP 67: Thomas Metzinger, author of The Ego Tunnel: The Science of the Mind and the Myth of the Self.

Announcements:

Ways to Support the BSP:

Tell me what you think:

To get show notes automatically and never miss an episode of the Brain Science Podcast sign up for the BSP newsletter.

The Origin of Emotions with Jaak Panksepp (BSP 91)

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Dr. Jaak Panksepp

In his new book, The Archaeology of Mind: Neuroevolutionary Origins of Human Emotions, Jaak Panksepp set out to make his life's work more accessible to a general audience.  To be honest, reading this book requires a significant commitment, but I think he does a wonderful job of updating his classic textbook, Affective Neuroscience.  Anyone who is interested in this field will definitely want this book as a reference.

The other strength of Archeology of Mind is its evolutionary approach.  The primary emotional processes that Panksepp has spent his career studying have their origins in the ancient parts of the brain that are shared by all mammals.  This contradicts longstanding assumptions in neuroscience, but it has important implications for both humans and other animals.

In Episode 91 of the Brain Science Podcast, Dr. Panksepp and I talked about some of the new information contained in Archaeology of Mind, with a particular focus on FEAR, which, contrary to what many researchers claim, does NOT begin in the amygdala, but begins much lower.  We do talk briefly about the experimental evidence, but this was covered in more detail during Dr. Panksepp's previous appearance on the Brain Science Podcast in BSP 65.

How to get this episode:

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • New episodes of the Brain Science Podcast are always FREE. All episodes posted after January 1, 2013 are FREE. Please see individual show notes for links to audio files and transcripts.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Related Episodes:

Announcements:

The earliest episodes of the Brain Science Podcast  are now disappearing from iTunes but they remain freely available here.  They are also available within the Brain Science Podcast  app for mobile devices.  By the way, the mobile app has been updated, and I need users to post new reviews.

Don't forget to get your copy of my eBook, Are You Sure? The Unconscious Origins of Certainty, from Amazon.com.  You can also buy the PDF version HERE.

The Brain Science Podcast is supported by listener Donations.  It also relies on your word of mouth, so don't forget to share it with others.

Next month's Brain Science Podcast  will be our annual review episode. Meanwhile don't forget to check out my other podcast, Books and Ideas.  The most recent episode is an interview with Emily Reese from Minnesota Classical Radio.

Join the Brain Science Podcast Fan Page on Facebook, Google+, and share your thoughts in our Discussion Forum on Goodreads.  Of course, you can also send me email at gincampbell at mac dot com.

To get show notes automatically and never miss an episode of the Brain Science Podcast sign up for the BSP Newsletter.

Review of "Self Comes to Mind" by Antonio Damasio (BSP 90)

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Episode 90 of the Brain Science Podcast is a discussion of Self Comes To Mind: Constructing the Conscious Brain, by Antonio Damasio. Damasio's book focuses on the answer to two key questions: How does the brain generate the Mind? and, How does the Brain generate Consciousness? His approach is unusual because many scientists and writers treat the Mind and Consciousness as identical. In contrast, Damasio argues that Mind precedes Consciousness. Listen to this podcast to learn how the Mind becomes Conscious.

How to get this episode:

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Related Episodes of the Brain Science Podcast: 

  • BSP 21 and BSP 23 How the Brain Creates Maps of the Body

  • BSP 65: Jaak Panksepp talks about the subcortical origins of emotions

  • BSP 89: Evan Thompson talks about his book, Mind in Life

Announcements:

  • Next month's Brain Science Podcast will be a return interview with Jaak Panksepp to talk about his new book, The Archaeology of Mind: Neuroevolutionary Origins of Human Emotions.

  • Please check out my other podcast, Books and Ideas.

  • The earliest episodes of the Brain Science Podcast are no longer available from iTunes but you can get them here or by buying the Brain Science Podcast app, which is available for iPhone, iPad, and Android.

  • Get my eBook, Are You Sure? The Unconscious Origins of Certainty, from Amazon.com for only $3.99.

  • Social Websites for the Brain Science Podcast: Discussion Forum on Goodreads, Facebook Fan Page, Google+ page.

  • Don't forget to get some high quality Brain Science Podcast Logo gear from Printfection.

  • Sign up for the Brain Science Podcast Newsletter so you never miss a new episode.

Send me feedback at brainsciencepodcast@gmail.com or follow me on Twitter (@docartemis).

"The Self Illusion" with Bruce Hood (BSP 88)

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Bruce Hood, PhD

 

The Self Illusion: How the Social Brain Creates Identity, by Bruce Hood, is a fascinating look at how our brains create both our experience of the world and our sense of being a single, coherent self.  As the word "illusion" in the title indicates, neither is exactly what it seems.  When I interviewed Dr. Hood (BSP 88), he explained that The Self Illusion is a broad introduction to this somewhat surprising idea. TheSelf Illusion was written with a general audience in mind.  For those already familiar with the topic, he also puts a new emphasis on the role of development.  All readers should come away with a new appreciation for the critical role social interactions play through out human life.

How to get this episode:

Related Podcasts:

Additional References:

Announcements:

Brain Aging Research with Dr. Pamela Greenwood (BSP 87)

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Pamela Greenwood, PhD

Nuturing the Older Brain and Mind, by Pamela M. Greenwood and Raja Parasuaman provides a comprehensive review of the current research in cognitive aging.  In the latest Brain Science Podcast (BSP 87), Dr. Greenwood explains that brain aging and cognitive aging are not the same thing; the typical brain changes that are associated with normal brain aging (such as shrinkage) are not reliable predictors of cognitive decline. Fortunately, even though normal brain aging is still not well understood, the discovery of brain plasticity is shifting the focus of research. Not only does brain plasticity offer new hope for people who suffer strokes and other brain injuries, it also suggests that life style choices influence cognitive function at all ages.

Nurturing the Older Brain and Mind is intended for an academic audience but it is accessible to everyone. This month's interview with Dr. Greenwood (BSP 87) focuses on dispelling the most stubborn myths about brain aging. We also talk about the practical steps we can all take to help maintain our cognitive performance.

How to get this episode:

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • New episodes of the Brain Science Podcast are always FREE. All episodes posted after January 1, 2013, are free. See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

Related Episodes:

  • BSP 10: Introduction to Brain Plasticity.

  • BSP 26: Norman Doidge, author of The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science.

  • BSP 28: Edward Taub: applying brain plasticity to stroke rehabilitation.

  • BSP 68: Peter Whitehouse on dementia versus normal brain aging.

References:

  • Nurturing the Older Brain and Mind, by Pamela M. Greenwood and Raja Parasuraman (2012).

  • The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science, by Norman Doidge.

  • Greenwood, P. M. (2007) Functional Plasticity in Cognitive Aging: Review and Hypothesis. Neuropsychology 21(6) 657–673.

  • Greenwood, P. M., and Parashauraman, R. (2010) Neuronal and cognitive plasticity: A neurocognitive framework for ameliorating cognitive aging. Frontiers in Aging Neuroscience 2: 150.

  • Gould, E. and Gross, C.G. (2002) Neurogenesis in adult mammals: Some progress and problems. Journal of Neuroscience 22 (3): 619-623.

  • Taub, E., Uswatte, G., and Elbert, T. (2002) New treatments in neurorehabilitation founded on basic research. Nature Reviews Neuroscience 3 (3): 228-236.

  • Grady, C. L., McIntosh, A.R., and Craik, F.I. (2003) Age-related differences in the functional connectivity of the hippocampus during memory encoding. Hippocampus 13 (5): 572-586.

  • Colcombe, S.J., A.F. Kramer, K.I. Erickson, P. Scalf, E. McAuley, N.J. Cohen, A. Webb, et al.,

  • Cardiovascular fitness, cortical plasticity, and aging. Proc Natl Acad Sci U S A, 2004. 101(9): p. 3316-21.

  • Hertzog, C., Kramer, A. F., Wilson, R. S. and Lindenberger, U. (2009) Enrichment effects on adult cognitive development: Can the functional capacity of older adults be preserved and enhanced? Psychological Science in the Public Interest 9 (1): 1-65.

  • Kramer, A.F., Larish, J. F., and Strayer, D. L. (1995) Training for attentional control in dual tasking settings: A comparison of young and older adults. Journal of Experimental Psychology: Applied 1: 50-76.

  • Nagamatsu, L.S., Handy, T. C., et. al. 2012. Resistance Training Promotes Cognitive and Functional Brain Plasticity in Seniors With Probable Mild Cognitive Impairment.Archives of Internal Medicine 172 (8) 666-668.

  • Liu-Ambrosea, T., Nagamatsua, L.S., Vosse, M.W., Khanc, K.M., and. Handy, T. C. (2012) Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial. Neurobiology of Aging 33: 1690 –1698.

  • Willis, S.L. et. al (2006) Long-term effects of cognitive training on everyday functional outcomes in older adults. Journal of the American Medical Association 296 (23): 2805-2814.

  • For more references: see Nurturing the Older Brain and Mind.

Announcements:

Terrence Deacon (Podcast Interview)

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In his new book, Incomplete Nature: How Mind Emerged from Matter, Terrence Deacon writes that his goal is to “demonstrate how a form of causality depending specifically on absent features and unrealized potential can be compatible with our best science.” (page 16).  But in a recent interview (Books and Ideas #47) he also contends that his book "grew out of a dissatisfaction with the systems theory approach."

He feels strongly that "to understand the origin of end-directed phenomena, representational phenomena, or mental phenomena, you need to take one further step; you need to figure out what’s beyond self-organization that needs to be explained to account for these things."  Thus, his ambitious goal is to find a place for meaning within science.

Incomplete Nature is a dense but compelling book, and the goal of this interview is to introduce listeners to the idea that life and meaning are compatible with a scientific world view. 

Sebastian Seung Explores the Brain's Wiring (BSP 85)

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Dr. Sebastian Seung (MIT) is an ambitious young scientist; his goal is to unravel the entire wiring diagram of the human brain.  Considering that it took over a decade to determine the wiring diagram for the roundworm C elegans, which has a mere 302 neurons, it is clear that scientists can't leap directly to the 80 billion neuron human brain.  Even so, in his new book Connectome: How the Brain's Wiring Makes Us Who We Are, Seung makes a very good argument for the value of this long-term project.  In Episode 85 of the Brain Science Podcast I talked with Dr. Seung both about the challenges and potential benefits of this work.

How to get this episode:

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References and Links:

Send me feedback at brainsciencepodcast@gmail.com.

Update on Consciousness Research with Christof Koch (BSP 84)

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Christof Koch, PhD

he scientific study of consciousness was once viewed with skepticism, but this has changed dramatically in recent years.   According to pioneering neuroscientist, Christof Koch, "the great thing is we’re not condemned to just sort of philosophical speculation, but we can make some predictions, and then go out and measure them.  And those are the things I talk about in this book, Confessions of a Romantic Reductionist." In Brain Science Podcast  #84, Koch reflects on the progress that has been made since I interviewed him back in 2007 (BSP 22), and he also talks about the latest initiatives at the Allen Institute for Brain Research, where he as recently become the chief science officer. 

How to get this episode:

  • Buy Audio (mp3) for $1.

  • Buy Transcript for $1.

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Announcements:

"Mind and Brain" with William Uttal (BSP 83)

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William Uttal, PhD

There is nothing more exciting than the mind/brain problem" according to Dr. William Uttal, author of Mind and Brain: A Critical Appraisal of Cognitive Neuroscience.  In the latest episode of the Brain Science Podcast  (BSP 83) I talked with Dr. Uttal about why he feels that brain imaging can not solve this mystery.

First, there is the problem that brain imaging represents the wrong level of analysis because every spot you see on a brain scan actaully represents thousands of neurons.  This means that the activity and interaction between individual neurons has been lost. Then there is the problem of reproducibility, with divergent results between studies.

The evidence is accumulating that "much of the brain responds to any stimulus, and every area of the brain participates in multiple functions."  This means that asking where a given function occurs may be the wrong question.

BSP 83 represents an on-going discussion of these issues, so I have included links to related episodes in the show notes. 

How to get this episode:

References: 

Related Podcasts:  

Reminders:

Send me feedback at gincampbell at mac dot.com.

How Mind Emerges from Brain (BSP 82)

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In his latest book, Who's in Charge?: Free Will and the Science of the Brain, respected neuroscientist, Michael S. Gazzaniga, explores how the discoveries of neuroscience impact how we see ourselves as human beings.  After providing a brief review of 20th century neuroscience, and even some of the work from the past decade, Dr. Gazzaniga concludes that nothing neuroscience has discovered changes the fact that "we are personally responsible agents and are to be held accountable for our actions."

Gazzaniga's position contrasts with those who think that recent discoveries show that the brain creates the mind in solely "upwardly causal" way, and who argue that since much of what our brain does is outside our conscious awareness or control, we should not be held responsible for our actions.  Who's in Charge?: Free Will and the Science of the Brain presents what I think is a convincing argument against this common position.

In the latest episode of the Brain Science Podcast (BSP 82) I present a detailed discussion of Dr. Gazzaniga's book.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Related Episodes:

  • Links to episodes of the Brain Science Podcast that are mentioned in BSP 82.

  • BSP 81: Interview with Patricia Churchland about the brain and morality.

  • BSP 53: Discussion of Did My Neurons Make Me Do It?: Philosophical and Neurobiological Perspectives on Moral Responsibility and Free Will by Nancey Murphy, Warren S. Brown.  (Also BSP 62)

  • BSP 35: Discussion of Mirror Neurons.

  • BSP 66: For more on scrub jays.

  • BSP 3: Memory and the use of animal models.

  • BSP 38: Interview with Jeff Hawkins.

  • BSP 47: Brain Evolution.

  • BSP 74: "Small world architecture" in brain networks (Olaf Sporns).

  • BSP 75: Interview with David Eagleman (arguments for legal reform).

  • BSP 76: "Choking" with Dr. Sian Beilock.

  • BSP 56: Interview with Eve Marder (implications of muliple realizability in neuronal circuits).

Announcements:

Send feedback to brainsciencepodcast@gmail.com.

Miguel Nicolelis, MD, PhD (BSP 79)

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Dr. Miguel Nicolelis at Duke University is pioneering brain-machine interfaces.  In his book, Beyond Boundaries: The New Neuroscience of Connecting Brains with Machines---and How It Will Change Our Lives, he puts his groundbreaking work into an historical context.  I discussed his book briefly in BSP 78, but I have now posted an in-depth interview.  The focus of our conversation is on why his work challenges longstanding assumptions about the primacy of the single neuron in brain function.

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Announcements:

Brain Machine Interfaces (BSP 78)

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In his book Beyond Boundaries: The New Neuroscience of Connecting Brains with Machines---and How It Will Change Our Lives neuroscientist Miguel Nicolelis puts his recent work with brain machine interfaces into historical context and explains why this work should change the way we understand how brains work.

Nicolelis challenges several long-standing assumptions including the primacy of the single neuron and strict localization, which is the idea that each area of the brain has a relatively fixed function.

Episode 78 of the Brain Science Podcast is a brief discussion of the key ideas presented in Beyond Boundaries, including a look at the implications of experiments such as the wide publicized work that culminated in demonstrating that a monkey in Nicolelis' lab at Duke (North Carolina, USA) could control a robot arm in Japan using only its brain. 

How to get this episode:

  • Premium Subscribers now have unlimited access to all old episodes and transcripts.

  • Buy mp3 for $1.

  • Buy Transcript for $1.

  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Related Episodes:

Announcements:

Neurobiology of Placebos with Fabrizio Benedetti (BSP 77)

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Fabrizio Benedetti, MD

 Fabrizio Benedetti is one of the world's leading researchers of the neurobiology of placebos.  In a recent interview (BSP 77) he explained to me that he believes that "today we are in a very good position to describe, from a biological and from an evolutionary approach, the doctor-patient relationship, and the placebo effect, itself."

To appreciate Dr. Benedetti's work, one must first realize that his approach differs from that of the typical clinical trial.  As he observed, "To the clinical trialist, a placebo effect means any improvement which may take place after placebo administration.  To the neurobiologist, a placebo response, or placebo effect means only something active in the brain happening after placebo administration: learning, anxiety reduction, activation of reward mechanisms."

In contrast, he explains, "The real placebo response, the real placebo effect is a psychobiological phenomenon.  It is something active happening in the brain after placebo administration: like learning, like anxiety reduction, and such like." Brain Science Podcast #77 provides an introduction to this complex, but fascinating topic.

How to get this episode:

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References

  • Benedetti F, Mayberg HS, Wager TD, Stohler CS, Jon-Kar Zubieta J (2005) Neurobiological Mechanisms of the Placebo Effect. The Journal of Neuroscience, 25,10390-10402. (Full article)

  • Benedetti F (2009) Placebo Effects: Understanding the mechanisms in health and disease. Oxford University Press.

  • Benedetti F (2011) The Patient's Brain: The neuroscience behind the doctor-patient relationship. Oxford University Press.

  • Levine JD, Gordon NC and Fields, HL (1978) The mechanisms of placebo analgesia. Lancet, 2, 654-7. (Abstract)

  • Levine JD, Gordon NC and Fields, HL (1978) “The mechanisms of placebo analgesia.” Lancet, 2, 654-7. (Abstract). See also a follow-up paper: Levine JD, Gordon NC, Bornstein JC, and H L Fields HL (1979) “Role of pain in placebo analgesia.” Proc Natl Acad Sci76(7): 3528–3531. (full text)

  • Volkow, ND, Wang JG, Ma Y, Fowler JS, Zhu W, Maynard L et al. (2003) Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. Journal of Neuroscience, 23, 11261–8. (Full text)

  • de la Fuente-Fernández R, et al. (2001) Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease. Science293, 1164. (Abstract)

  • Benedetti F, Colloca L, Torre E et al. (2004) Placebo-responsive Parkinson patients show decreased activity in single neurons of the subthalamic nucleus. Nature Neuroscience, 7, 587-88. (Abstract)

  • Herrnstein RJ, (1962) Placebo Effect in the Rat. Science138, 677-678.

  • Linde K, Witt CM, Streng A et al. (2007) The impact of patient expectation in four randomized control trials of acupuncture in patients with chronic pain. Pain, 128, 264-71. (Abstract)

Announcements

Corrections

  •  32:48 only NON-members are eligible to get a free audiobook download from our sponsor at http://audiblepodcast.com/brainscience.

  • Dr. Benedetti’s first book is called Placebo Effects, not Placebo “responses”.

  • Special Thanks to Lori Wolfson for finding these mistakes and correcting them in the episode transcript.

Send me feedback at gincampbell at brainsciencepodcast@gmail.com

David Eagleman on The Secret Lives of the Brain (BSP 75)

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David Eagleman, PhD

In his new book, Incognito: The Secret Lives of the Brain, neuroscientist, David Eagleman, describes consciousness as "the smallest player in the operations of the brain" (page 5) because most of what the brain does is outside conscious awareness (and control).  In a recent interview (BSP 75), Dr. Eagleman reviews some of the evidence for this startling position, as well as the implications both for the average person and for social policy.

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  • New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

Listen in your Favorite Audio app: Audible, Amazon music, Pandora, Spotify, YouTube and many more.

References:

Related Episodes of BSP:

  • BSP 13: Our first discussion of unconscious decisions.

  • BSP 15: Interview with Read Montague, PhD, author of Why Choose This Book?: How We Make Decisions.

  • BSP 19: Review of Gut Feelings: The Intelligence of the Unconscious, by Gerd Gigerenzer.

  • BSP 42: Review of On Being Certain: Believing You Are Right Even When You're Not, by Robert Burton.

  • BSP 43: Interview with Robert Burton, MD.

Send me feedback at brainsciencepodcast@gmail.com.

"Why Neuroscience Matters"

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On May 11, 2011 I gave a talk entitled "Why Neuroscience Matters" at the London Skeptics in the Pub.  Episode 42 of Books and Ideas is an edited version of that talk, including the lively Q and A with the audience.

References

From the Brain Science Podcast

Announcements:

  • Dr. Campbell will be a speaker at The Amazing Meeting 9, which is coming up in Las Vegas, Nevada July 14-17.

Please send your feedback to Dr. Campbell at gincampbell at mac dot com, or post a comment on the Facebook Fan Page.

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