Connectome Update (BSP 103)

Olaf Sporns, PhD

The Human Connectome is a description of the structural connectivity of the human brain, but according to Olaf Sporns, author of Discovering the Human Connectome, this description  must include a description of the brain's dynamic behavior. I first talked with Sporns back in BSP 74, but BSP 103 gave us a chance to talk about recent progress in connectomics.

Sporns sees the study of the brain's connections as fundamental to understanding how the brain works.

"It will allow us to ask new questions that perhaps we couldn’t ask before. It will be a foundational data set for us, just like the genome is. We will not be able to imagine neuroscience going back to a time when we did not have the connectome, but it will not give us all the answers.”

In his first book, Networks of the Brain, Sporns described how Network Theory provides important tools for dealing with the large data sets that are created by studying complex systems like the human brain.  In BSP 103 we discuss both the challenges and the promise of Discovering the Human Connectome. 

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Sebastian Seung Explores the Brain's Wiring (BSP 85)

Dr. Sebastian Seung (MIT) is an ambitious young scientist; his goal is to unravel the entire wiring diagram of the human brain.  Considering that it took over a decade to determine the wiring diagram for the roundworm C elegans, which has a mere 302 neurons, it is clear that scientists can't leap directly to the 80 billion neuron human brain.  Even so, in his new book Connectome: How the Brain's Wiring Makes Us Who We Are, Seung makes a very good argument for the value of this long-term project.  In Episode 85 of the Brain Science Podcast I talked with Dr. Seung both about the challenges and potential benefits of this work.

How to get this episode:

• Buy audio mp3 for $1.

• Buy Transcript for $1.

• Premium Subscribers now have unlimited access to all old episodes and transcripts.

• New episodes of the Brain Science Podcast are always FREE.  All episodes posted after January 1, 2013, are free.  See the individual show notes for links the audio files.

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References and Links:

• Connectome: How the Brain's Wiring Makes Us Who We Are, by Sebastian Seung.

• Sporns O, Tononi G, Kötter R (2005) The Human Connectome: A Structural Description of the Human Brain. PLoS Comput Biol 1(4): e42. doi:10.1371/journal.pcbi.0010042.

• White, J. G., E. Southgate, J. N. Thomson and S. Brenner. (1986) The Structure of the Nervous System of the Nematode Caenorhabditis elegans, Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 314 (1165) 1-340. doi: 10.1098/rstb.1986.0056.

• EyeWire.org: where you can help unravel the wiring diagram of the human retina.

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