Explore the Synaptome with Seth Grant (BS 150)

Explore the Synaptome with Seth Grant (BS 150)

BS 150 is our 4th interview of Seth Grant, the molecular biologist who has uncovered the fascinating evolution of synapse complexity. In this interview we learn about the first whole brain mapping of the mouse brain synaptome. We discuss the implications of the surprising level of diversity found in synapses in different brain areas. Dr Grant introduces us to a new theory of perception and memory recall.

Read More

Synapse Evolution with Seth Grant (BSP 101)

Seth Grant (click photo to hear interview)

Seth Grant (click photo to hear interview)

Early in his career Seth Grant helped develop the transgenic mice that Eric Kandel used in his studies of how memory works. Since then he has combined his skill in genetics with his work on isolating the proteins that form the functional components of the synapse. (The synapse is a key component in the nervous systems of all multi-cellular animals.) When we last talked back in BSP 51 I was particularly struck by how many of these proteins actually evolved with single celled life--long before the arrival of nervous systems.

Recently Grant's work has focused on the discovery that the vertebrate synapse is actually much more complex than the one present in invertebrates. For BSP 101 we got together to talk about two papers he and his collegues recently published in Nature Neuroscience. These papers explore how small changes in the synapse proteins effect learning in measurable ways.

Grant has a special gift for making complex ideas clear, which means that this interview can be enjoyed by all listeners, even those who are new to the Brain Science Podcast and neuroscience. 

How to get this episode:


  • S.G.N. Grant, T. J. O'Dell, K. A. Karl, P. L. Stein, P. Soriano, and E. R. Kandel, "Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice." Science 258 (1992):1903-10.

  • Emes RD, Pocklington AJ, Anderson CN, Bayes A, Collins MO, Vickers CA, Croning MD, Malik BR, Choudhary JS, Armstrong JD, Grant SG, "Evolutionary expansion and anatomical specialization of synapse proteome complexity." Nature Neuroscience 11 (2008) 799-806.

  • Nithianantharajah, J., Komiyama, N., McKechanie, A., Johnstone, M., Blackwood, D. H., Clair, D. S., Emes, R. D., van de Lagemaat, L. N., Saksida, L. M., Bussey, T. J. & Grant, S. G. N. “Synaptic scaffold evolution generated components of vertebrate cognitive complexity.” Nature Neuroscience 16 (2013) 16-24. doi:10.1038/nn.3276

  • Ryan, T. J., Kopanitsa, M. V., Indersmitten, T., Nithianantharajah, J., Afinowi, N. O., Pettit, C., Stanford, L. E., Sprengel, R., Saksida, L. M., Bussey, T. J., O'Dell, T. J., Grant, S. G. N. & Komiyama, N. “Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior.” Nature Neuroscience 16 (2013) 25-32. doi:10.1038/nn.3277

  • List of research papers by Seth Grant

  • See FREE transcript for more links and references

  • More episodes about brain evolution: BSP 47, BSP 48, and BSP 51


Leave feedback here or visit the Brain Science Podcast discussion group at Goodreads.com, our Fan Page on Facebook or our page on Google+.