Review: "Principles of Brain Evolution" (BSP 47)

Episode 47 of the Brain Science Podcast is a discussion of Principles of Brain Evolution by Georg F. Striedter.  My goal is to highlight the main ideas of this complicated and often controversial subject.  Understanding the principles of brain evolution is an important element in our multidisciplinary attempt to understand how our brains make us who we are.

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Show Notes and Links:

Important terms:

  • homologues: characteristics with shared ancestry.

  • neurocladistics: a rigorous method for classifying neural structures based on their ancestry.

  • small-world network: a mathematical graph where most nodes connect to nearby nodes but almost any two can be connect in relatively small number of steps (the famous six-degrees of separation).

  • Boskop man: an extinct hominid that is thought to have had a larger brain than modern humans.

People and scientists discussed:

Announcements:

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"All in the Mind" Looks at Brain Plasticity

Recently Natasha Mitchell did an excellent two-part All in the Mind  podcast about brain plasticity.  In Part 1, she interviewed Jeffrey Schwartz, MD and Norman Doidge, MD.  Dr. Schwartz is the author of The Mind and the Brain: Neuroplasticity and the Power of Mental Force, and Dr. Doidge wrote the recent bestseller,The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science.

In Part 2, Mitchell interviews Dr. Doidge further.  One of the topics they explore is the "dark side" of plasticity.  Since neuroplasticity is a dynamic, competitive process, it is actually a factor in how we form our habits, both good and bad . This interview is an excellent follow-up to the interview Dr. Doidge did for the Brain Science Podcast back in Episode 26.

You can listen to the podcasts and get transcripts at the All in the Mind website.

Brain Imaging: Recorded LIVE at Dragon*Con 2008 (BSP 46)

Dr. Campbell at Dragon*Con 2008

Brain Science Podcast #46 is a discussion of brain imaging with Dr. Shella Keilholz and Dr. Jason Schneiderman.  The focus of our discussion is functional magnetic resonance imaging (fMRI), which is revolutionizing neuroscience.  We talked about both the strengths and weaknesses of this technique.  Both of my guests agree that mainstream coverage of this technique tends to exaggerate what we can actually tell from this kind of brain scan.  An important principle is that the scan of any single individual can vary greatly from day to day, which means that valid conclusions require data from a large number of people.

Since this episode was recorded LIVE in the Podcasting Track at Dragon*Con 2008, it includes audience questions at the end, which helped bring out additional ideas.  I have posted an edited version (but there is still some noise from the room next door).  If you are interested in hearing the raw unedited version, click here.  I also want to thank Swoopy from Skepticality for all the work she did to make the podcasting track a great success.

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More about my guests:

Shella Keilholz, PhD, is an assistant professor of Biomedical Engineeering at Georgia Tech and the Emory School of Medicine in Atlanta, GA.  She is doing studies that involve correlating fMRI scans with the reading from electrodes placed in rat brains.  This work is fundamental to improving the correlation between fMRI scans, which reflect brain activity only indirectly, and what is actually happening in the neurons of the brain.

Jason Schneiderman, PhD studied psychology before earning his PhD in neuroscience.  His dissertation involved the use of diffusion tensor imaging, which is a new method of scanning that is being used to track the axonal connections in the brain.  He is currently doing a post-doctoral fellowship at Harvard Medical School, where his team is trying to determine if the connections in the brains of young schizophrenics are different from normal.  The goal is to improve early diagnosis because early intervention makes a big difference.

Some recent discussions of fMRI:

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John Ratey, MD Discusses ADD (BSP 45)

Have you ever wondered why a child with ADD can play videos games for hours, but can't concentrate on his homework for a few minutes?  This is one of the paradoxes of attention-deficit disorder that John J Ratey, MD, co-author of, Driven To Distraction : Recognizing and Coping with Attention Deficit Disorder from Childhood Through Adulthood, explains in Episode 45 of the Brain Science Podcast.

During this interview, Dr. Ratey discusses the latest findings about the biological basis of what he calls "attention variability disorder."  He also offers practical advice for patients and parents dealing with ADD/ADHD.  One very important, and somewhat surprising, fact that he shares is that patients who are treated with medications during adolescence have a significantly lower risk of developing problems with addiction and drug abuse later on compared to those who are not treated.  Also, successful "ADD-ers" like Michael Phelps show that "having a mission" makes a huge difference.

Dr. Ratey's most recent book is Spark: The Revolutionary New Science of Exercise and the Brain, which he discussed with me (Dr. Campbell) in Episode 33.

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Detailed Show Notes

Topics discussed:

  • Why our current cyber-culture  exacerbates symptoms.

  • The genetic component.

  • The role of dopamine and epinephrine.

  • The relationship between ADD and addiction.

  • Why ADD effects all the brain systems including memory.

  • The importance of strengthening executive (frontal lobe) function.

Successful people with ADD:

  • Michael Phelps-winner of 8 Gold Medals for Swimming in 2008 Olympics.

  • Rick Warren-founder of The Purpose Driven Church.

Practical Advice:

  • the need for a mission.

  • environmental changes.

  • the role of meditation and exercise.

  • why stimulant medication helps.

  • training the cerebellum.

  • Omega 3 Fatty Acids (Dr. Ratey recommends OmegaBrite™).

Links:

Send email feedback to Ginger Campbell, MD at brainsciencepodcast@gmail.com

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Meditation and the Brain with Daniel Siegel, MD (BSP 44)

Daniel Siegel, M.D.

In Episode 44 of the Brain Science Podcast I talk with Daniel Siegel, MD about meditation and the brain.  Dr. Siegel is the author of several books including The Mindful Brain: Reflection and Attunement in the Cultivation of Well-Being.  In this interview, we review the scientific evidence about how mindfulness meditation changes the brain, both in terms of short term activity and in terms of long-term structural changes.  The evidence is convincing that a regular mindfulness practice can be an important element of brain health.

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Show Notes and Links:

Daniel J. Siegel, M.D.:

Scientists and writers mentioned in Episode 44:

More information about meditation:

Note: Insight Meditation is based of vipassana meditation, the mindfulness practices of Theravada, the oldest branch of Buddhism.  Insight Meditation is easily adapted to secular purposes because it not based on beliefs or dogmas.  The most well-known secular form is called mindfulness meditation, which begins with a focus on breath awareness and then advances to developing compassion for oneself and others.

Researchers are studying people who practice other types of mediation also. Richard Davidson has focused his work on the study of Tibetan Buddhist monks.  Their practice emphasizes the development of compassion.

*I discussed the therapeutic use of mediation with Delany Dean, PhD, in Episode 20 of Books and Ideas.

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From SharpBrains: Neurogenesis and Brain Plasiticity

In her latest post for SharpBrains Laurie Bartels reviews some of the principles of brain plasticity.  One principle that she mentions that I think deserves more attention is the importance of learning new things.

Adults may have a tendency to get set in their ways – I’ve been doing it this way for a long time and it works, so why change?  Turns out, though, that change can be a way to keep aging brains healthy.  At the April Learning & the Brain conference, the theme of which was neuroplasticity, I attended several sessions on adult learning. (Click here to read Laurie's post.)

She goes on to review the highlights of the Learning and Brain Conference.  You can read the full post at: http://www.sharpbrains.com/blog/2008/08/07/neurogenesis-and-brain-plasticity-in-adult-brains/

"On Being Certain": Interview with Robert Burton, MD (BSP 43)

BSP 43 is an interview with Robert A Burton, MD, author of On Being Certain: Believing You Are Right Even When You're NotThis is a follow up to BSP 42.

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Other scientists/writers mentioned in this episode:

Other terms mentioned in the interview:

  • Cotard's Syndrome: when the patient believes they do not exist or that they are dead

  • Cognitive dissonance: a mismatch between what one believes and what the evidence supports

Previous Episodes of the Brain Science Podcast:

  • Episode 42: Part 1 of our discussion of On Being Certain.

  • Episode 13: Unconscious Decisions-featuring Blink, by Malcom Gladwel.l

  • Episode 15: Interview with Read Montague about unconscious decisions.

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Don't Miss Neuroscience Pioneer, Dr. Brenda Milner, on Futures in Biotech

In Episode 33 Futures in Biotech  host Marc Pelletier, PhD, interviews pioneering researcher, Dr. Brenda Milner from the Montreal Neurological Institute.  Dr. Milner is best known for her work with HM, the patient that she worked with for many decades.  Her work helped neuroscientists appreciate the role of the hippocampus in memory and the fact that there are multiple types of memory, some of which do not require the hippocampus.

One of the things that makes this interview special is that Dr. Milner gives us the inside story on some of the pioneering work that we now take for granted.  She emphasizes how the work fit into the context of its time, giving an unique glimpse into the history of how science really unfolds.

Click here to learn more.

Futures in Biotech is a valuable contributor to SCIENCEPODCASTERS.ORG.

Review: "On Being Certain" (BSP 42)

Episode 42 of the Brain Science Podcast is a discussion of On Being Certain: Believing You Are Right Even When You're Not, by Robert Burton, MD.  This Part 1 of a two-part discussion of the unconscious origins of what Dr. Burton calls "the feeling of knowing."  In Episode 43 I will interview Dr. Burton. Today's episode provides an overview of Dr. Burton's key ideas.

In past episodes I have discussed the role of unconscious decision-making.  On Being Certain: Believing You Are Right Even When You're Not ,by Robert Burton, MD, takes this topic to a new level.  First, Dr. Burton discusses the evidence that the "feeling of knowing" arises from parts of our brain that we can neither access or control.  Then he discusses the implications of this finding, including the fact that it challenges long-held assumptions about the possibility of purely rational thought.

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References and Links:

Other scientists mentioned in this episode:

  • Leon Festinger-proposed the theory of cognitive dissonance in 1957.

  • Joseph Ledoux-research with rats and the role of the amygdala in the fear response.

  • Michael Merzenich-showed how the auditory cortex in young rats is affected by experience.

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Alice Gaby Talks About Linguistics (BSP 41)

Episode 41 of the Brain Science Podcast is an interview with Alice Gaby, PhD, from the University of California-Berkeley.  Dr. Gaby is a linguist who studies the role of language in cognition as well as the aboriginal languages of Australia . In this episode, Dr. Gaby introduces some of the basic areas of linguistics.  We also talk about why linguistics is important to understanding brain function, as well as the importance of interdisciplinary communication to advancement in both fields.  Dr. Gaby's infectious enthusiasm makes this potentially intimidating subject accessible to everyone.

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Links and References:

Other scientists mentioned in the interview:

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"All in the Mind" Explores the Implications of Cognitive Enhancement

The June 14 Episode of All in the Mind has a thoughtful discussion of the implications of using drugs to improve cognitive performance. Natasha Mitchell interviewed Barbara Sahakian, professor of Neuropsychology at the University of Cambridge (UK) and William Glannon, a bioethicist from the University of Calgary (Canada). Several important issues emerged including the fact that that it is unknown whether the drugs currently available are safe for long-term use. There is also the nagging question of whether the use by normal people of drugs originally intended to treat medical conditions (like ADHD) constitutes cheating? What do you think? You can find the podcast and its transcript here. If you want to share you opinion with Natasha go to her All in the Mind Blog.

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Cognitive Computing: Videos from 2007

Last week I had Dr. Michael Arbib on the Brain Science Podcast. While our discussion focused on his work related to mirror neurons, we also talked a little about his general area of expertise, which is cognitive neuroscience. Most of us don't have a real feel for what this field involves, but those of you who are interested in learning more might want to check out  the archive of videos from Cognitive Computing 2007, which was held at UC-Berekeley on May 2 and 3 last year. The site includes Dr. Arbib's presentation "From Cognitive Neuroscience to Computer Archictectures." http://cognitivecomputing2007.berkeley.edu/CognitiveComputing2007Video.htm
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Mirror Neurons with Michael Arbib (BSP 39)

Episode 39 of the Brain Science Podcast is an interview with Dr. Michael Arbib from the University of Southern California.  Dr. Arbib's work with functional brain imaging has established the presence of mirror neurons in the human brain.  In our interview, we focused on the role of mirror neurons in imitation and language.  In particular, I questioned Dr. Arbib about the Mirror System Hypothesis (MSH) of Language Evolution that he proposed in 1998 with Giacomo Rizzolatti.  We also explored how this hypothesis diverges from the universal grammar proposed by Noam Chomsky.  Dr. Arbib also shared his enthusiasm for future research and we talked about the special challenges caused by the interdisciplinary nature of modern neuroscience.

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Related Episodes:

Scientists mentioned in the interview:

  • Giacomo Rizzolatti: His team discovered mirror neurons at the University of Parma, Italy. Other team members: Vittorio Gallese, Luciano Fadiga, and Leo Fogassi.

  • Ursula Bellugi (Salk Institute): pioneered the neurobiology of sign language.

  • Richard Byrne (University of St. Andrews): studies how gorillas learn in the wild.

  • Michael Tomasello (Max Planck Institute for Comparative Anthropology): studies social behavior of primates, including how communicative gestures vary between groups.

  • Noam Chomsky (MIT): famous linguist who has proposed an inborn universal grammar.

  • DL Cheney and RM Seyfarth:  research about primate vocal behavior, especially the use of calls in the wild.

References:

Other Links:

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Interview with Jeff Hawkins "On Intelligence" (BSP 38)

Episode 38 of the Brain Science Podcast is an interview with Jeff Hawkins, author of On Intelligence.  Hawkins is well-known for founding Palm Computing and Handspring.  He invented the Grafitti handwriting recognition system and helped develop the Palm Trio SmartPhone.  Since he published his bestseller On Intelligence, he has devoted his work to his passion for neuroscience.  His current company, Numenta, is developing software that models the hierarchical structure of the neocortex.  In this interview we talk about the ideas in Hawkins book and how he is applying them to develop a computer model of cortical function.  This is a follow-up to Episode 2, which first aired in December of 2006.

How to get this episode:

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Links and References:

Vernon Montcastle: pioneer who proposed that all parts of the brain's cortex work the same way.

  • Vernon Mountcastle (1978), "An Organizing Principle for Cerebral Function: The Unit Model and the Distributed System", The Mindful Brain (Gerald M. Edelman and Vernon B. Mountcastle, eds.) Cambridge, MA: MIT Press (Please let me know if you find this paper on-line!)

Redwood Institute for Theoretical Neuroscience (UC-Berkeley) founded by Jeff Hawkins.

Numenta: company website includes extensive educational information about hierarchical temporal memory system (HTM).  The company's focus is practical implementation of HTM Theory.

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"Brain Rules" with John Medina (BSP 37)

John Medina, PhD

Episode 37 of the Brain Science Podcast is an interview with Dr. John Medina, author of Brain Rules: 12 Principles for Surviving and Thriving at Work, Home, and School.  We talk about how exercise, sleep, and stress effect our brains, with an emphasis on practical advice for healthier brain function.  We also look at how research on memory, vision, and the brain's attention system suggests how we can improve our ability to learn and our ability to share ideas with others.

Dr. Medina's focus is on considering real world examples of how our schools and work environments could be reformed to utilize the growing knowledge of neuroscience.  But he also stresses the importance of compiling sufficient experimental data before embarking on new programs.

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Links and References:

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"All in the Mind" Looks at Nicotine and the Brain

The May 10th episode of All in the Mind is an excellent discussion of the latest research about nicotine addiction.  It includes a very balanced look at the controversy over the new smoking cessation drug, varenicline, which is sold in the US as Chantix.  Nicotine has a unique effect on certain neurotransmitter receptors in the brain.  Varenicline works as a partial agonist, which means it mimics some of the effects of nicotine, but it also blocks the receptor so that when a person smokes the experience is not rewarding.  However, since the receptors involved also have other functions (they aren't there to respond to the nicotine in cigarettes just like the opiate receptors are not there to respond to man-made narcotics), using the drug can lead to a wide variety of side effects. Balancing the risks and benefits of the drug is one of the topics discussed in the podcast.

I have to admit that addiction is a subject in which I have little personal interest, but obviously addiction to smoking effects millions of people. I highly recommend this podcast to everyone who smokes or loves some who does.

Be sure to go to the site for both the show's transcript and links to everyone featured on the show.

http://www.abc.net.au/rn/allinthemind/stories/2008/2235816.htm

Embodied Cognition with Art Glenberg (BSP 36)

Episode 36 of the Brain Science Podcast is an interview with Arthur Glenberg, PhD, about embodied cognition.  Dr. Glenberg recently moved to Arizona State University, after over 30 years at the University of Wisconsin's Laboratory of Embodied Cognition.  His research focuses on the relationship between embodiment and language.  In this interview, we explore the experimental evidence for a theory of language that embraces the concept that our language abilities are actually rooted in our perceptual and motor abilities.  Dr. Glenberg also explains how his work has practical implications in helping children learn how to read.

Since Dr. Glenberg has had a long career as a working research scientist, this interview also provided an opportunity to explore how scientific hypotheses are formed and how experiments are designed to test these hypothesis.  I think this interview will give you a fascinating look into the real world of cognitive psychology.

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Links and References:

Arthur Glenberg, PhD

Other scientists mentioned in the Episode:

  • George Lakoff: pioneering linguist.

  • James Gibson: known for his ideas about affordances.William Epstein-emeritus professor at the University of Wisconsin.

  • Joseph Campos: University of California (Berkelely).

  • Amy Needham and Amanda Woodard-experiments with velcro mits and infant cognition.

  • David A Havas: graduate student and co-author with Dr. Glenberg.

  • Mike Kashak: Florida State University.

  • Mike Rinck: German co-author-see paper under Glenberg.

  • Vittorio Gallese, Dept of Neuroscience, University of Parma, Italy (where mirror neurons were discovered): extensive experimental with motor neurons in monkeys.

  • Fritz Stack (Germany): experiments showing that facial experiments affect mood and cognition.

References:

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A Closer Look at Mirror Neurons (BSP 35)

Brain Science Podcast #35 is a discussion of Mirrors in the Brain: How Our Minds Share Actions, Emotions, and Experience, by Giacomo Rizzolatti and Corrado Sinigaglia.  Mirror neurons were discovered in Rizzolatti's lab in Parma, Italy, in the early 1990s, and his book is a detailed to discussion of the experimental evidence in both monkeys and humans.  Direct single neuron recordings have been made in monkeys.  The evidence in humans is indirect, since it is based on mainly on neuro-imaging studies like PET scans and fMRI scans.  Even so, mirror neurons appear to be essential to our ability to understand both the actions and emotions of others. 

In this episode, we also explore the evidence that there are other neurons in the motor areas of the brain that have sensory properties and that the areas of the brain traditionally thought to be devoted to sensory functions also contain neurons with motor properties.  Another fascinating discovery is the fact that there are neurons that respond not only to somatosensory inputs (such as being touched) but also to visual or auditory inputs from objects within our peri-personal space.  For background on these body maps, I recommend listening to Episode 21 and Episode 23.  If you are new to the Brain Science Podcast, you may want to listen to those episodes first, because this week's episode is a little more technical than most.

I will be exploring the importance of these discoveries in future episodes.

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Links:

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Dan Rather's Reports on Neuroplasticity

Today HDNet™ is re-showing an episode of Dan Rather Reports called "Mind Science."  It is an excellent review of neuroplasticity. It includes interviews with several leading scientists in the field.  I especially enjoyed seeing Nobel Laureate, Eric Kandel, talk about his work with memory.  (I talked about Kandel's work on the Brain Science Podcastin Episode 3 and Episode 12.)

"Mind Science" also features the Dalai Llama and scientist, Richard Davidson, talking about the evidence that meditation can change the brain.  Rather interviews Sharon Begley about her book, Train Your Mind, Change Your Brain: How a New Science Reveals Our Extraordinary Potential to Transform Ourselves  (which I discussed in detail in Episode 10 of the Brain Science Podcast).  Other scientists featured in the episode include Michael Merzenich on improving brain function as we age, and Dr. Edward Taub on his revolutionary approach to stroke rehabilitation.  (My show notes for Episode 10 include links for all the scientists interviewed by Rather.)

It was particulary gratifying to see Dr. Kandel endorse Ed Taub's Constraint-Induced Movement Therapy.  Dr. Taub was interviewed in Episode 28 of the Brain Science Podcast.  If you don't get HDNet™, you can watch Dan Rather Reports on-line, via podcast or on Facebook.

Summary of relevant episodes of the Brain Science Podcast::