BS 205 is a follow-up interview with molecular biologist Dr. Guy Caldwell we learn more about how the tools of molecular biology are used to unravel questions in neurobiology and provide hope for better treatments for problems like Parkinson's Disease.

We learn about how gene editing techniques are used test the effects of single nucleotide changes in the neurons of the roundworm C. Elegans. This is possible because humans and C. Elegans share many genes. This makes it possible to economically explore a wide range of possibilities.

Dr. Caldwell’s lab at the University of Alabama provides a unique opportunity for undergraduates to participate in meaningful research and near the end of this interview he also share the accomplishments of several of his students.

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Links and References:

• Guy Caldwell, PhD (University of Alabama)

  • LinkedIn 

  • BS 204 Encore of 2009 interview

• The Worm Shack

• Mew, M., Caldwell, K. A., & Caldwell, G. A. (2022). From bugs to bedside: functional annotation of human genetic variation for neurological disorders using invertebrate models. Human molecular genetics, 31(R1), R37–R46. https://doi.org/10.1093/hmg/ddac203

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